Evidence map›Paper›PMID 37364987›Full record

ReviewGenes & development2023

Circadian mechanisms in adipose tissue bioenergetics and plasticity.

Chelsea Hepler, Joseph Bass

Open access · diamondAbstract readReview
In one paragraph

Review in Genes & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. [Interactions among circadian rhythm, obesity, and inflammation and their regulation by exercise].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. NADH dehydrogenase reverses dietary and clock metabolic syndrome.bioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Human brown fat and metabolic disease: a heated debate.The Journal of clinical investigation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chelsea HeplerDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.ORCID 0000-0001-9938-382X
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA j-bass@northwestern.edu.
Northwestern University · US

Funding

SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity PathophysiologyR01DK127800 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2021 to 2025
$2.3M
Circadian SCN-Liver Axis in the Neuroendocrine Response to Calorie RestrictionR01DK132647 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 2023 to 2026
$2.1M
Bioenergetic Mechanisms Underlying Circadian Dietary InterventionR01AG065988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2019 to 2023
$2.0M
The Circadian System as a Neuronal Regulator of Feeding Time and Body Weight SetpointR01DK113011 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2018 to 2021
$1.7M
A Central Circadian Clock-Adipose Tissue Circuit Regulates Thermogenesis and Energy BalanceF32DK122675 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HEPLER, CHELSEA · 2020 to 2023
$204k
NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG065988NIDDK NIH HHS F32 DK122675NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK113011NIDDK NIH HHS R01 DK127800NIDDK NIH HHS R01 DK132647
6 · The paper itself

Abstract

The circadian clock plays an essential role in coordinating feeding and metabolic rhythms with the light/dark cycle. Disruption of clocks is associated with increased adiposity and metabolic disorders, whereas aligning feeding time with cell-autonomous rhythms in metabolism improves health. Here, we provide a comprehensive overview of recent literature in adipose tissue biology as well as our understanding of molecular mechanisms underlying the circadian regulation of transcription, metabolism, and inflammation in adipose tissue. We highlight recent efforts to uncover the mechanistic links between clocks and adipocyte metabolism, as well as its application to dietary and behavioral interventions to improve health and mitigate obesity.

Indexed as

Adipose TissueCircadian ClocksCircadian RhythmEnergy MetabolismHumansObesityadipocyteadipose tissuecircadian clockcircadian rhythmsinflammationmetabolismplasticitythermogenesistranscription

Identifiers

PMID37364987
PMCPMC10393195
OpenAlexW4382139742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.