Evidence map›Paper›PMID 37364376›Full record

ArticleThe Journal of infectious diseases2023

Association Between Maternal Breastmilk Microbiota Composition and Rotavirus Vaccine Response in African, Asian, and European Infants: A Prospective Cohort Study.

Jonathan Mandolo, Edward P K Parker, Christina Bronowski, Kulandaipalayam Natarajan C Sindhu, Alistair C Darby, Nigel A Cunliffe, Gagandeep Kang, Miren Iturriza-Gómara, Arox W Kamng'ona, Khuzwayo C Jere

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Jonathan MandoloVirology Research Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0003-0143-7469
Edward P K ParkerDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Christina BronowskiDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Kulandaipalayam Natarajan C SindhuWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Alistair C DarbyDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Nigel A CunliffeDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Gagandeep KangWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0000-0002-3656-564X
Miren Iturriza-GómaraCentre for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Geneva, Switzerland.
Arox W Kamng'onaVirology Research Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Khuzwayo C JereVirology Research Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0003-3376-8529
University of Liverpool · GBChristian Medical College, Vellore · INLondon School of Hygiene & Tropical Medicine · GBProgram for Appropriate Technology in Health · US

Funding

Medical Research Council MR/N006259/1Wellcome TrustWellcome Trust 201945/Z/16/Z
6 · The paper itself

Abstract

backgroundMaternal breastmilk is a source of pre- and pro-biotics that impact neonatal gut microbiota colonization. Because oral rotavirus vaccines (ORVs) are administered at a time when infants are often breastfed, breastmilk microbiota composition may have a direct or indirect influence on vaccine take and immunogenicity.

methodsUsing standardized methods across sites, we compared breastmilk microbiota composition in relation to geographic location and ORV response in cohorts prospectively followed from birth to 18 weeks of age in India (n = 307), Malawi (n = 119), and the United Kingdom ([UK] n = 60).

resultsBreastmilk microbiota diversity was higher in India and Malawi than the UK across 3 longitudinal samples spanning weeks of life 1 to 13. Dominant taxa such as Streptococcus and Staphylococcus were consistent across cohorts; however, significant geographic differences were observed in the prevalence and abundance of common and rare genera throughout follow up. No consistent associations were identified between breastmilk microbiota composition and ORV outcomes including seroconversion, vaccine shedding after dose 1, and postvaccination rotavirus-specific immunoglobulin A level.

conclusionsOur findings suggest that breastmilk microbiota composition may not be a key factor in shaping trends in ORV response within or between countries.

Indexed as

MicrobiotaRotavirusRotavirus InfectionsRotavirus VaccinesAntibodies, ViralFemaleHumansImmunoglobulin AInfantInfant, NewbornMilk, HumanProspective StudiesVaccines, AttenuatedAntibodies, ViralImmunoglobulin ARotavirus VaccinesVaccines, Attenuatedbreastmilkimmunogenicitymicrobiotarotavirus

Identifiers

PMID37364376
PMCPMC10469347
OpenAlexW4382181531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.