ArticleEnvironment international2023
Metal mixtures and DNA methylation measures of biological aging in American Indian populations.
Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Chemical and climatic environmental exposures and epigenetic aging: A systematic review.Environmental research · 2025Pooled it
- Associations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging.Cardiovascular toxicology · 2026Article
- Association between essential trace elements, dietary patterns, and biological aging.European journal of nutrition · 2026Article
- Article
- What's counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations.Clinical epigenetics · 2025Review
- Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II).Clinical epigenetics · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Environmental Health Is Overlooked in Longevity Research.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Article
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- Association of blood cadmium levels with epigenetic age acceleration in U.S. adults aged > 50 years.Frontiers in public health · 2025Article
- Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging.Frontiers in nutrition · 2025Article
- Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among U.S. adults.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study.Environment international · 2024Article
- Article
- Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA).Analytical methods : advancing methods and applications · 2024Article
- Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
introductionNative American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based "clocks" can be used to estimate accelerated biological aging that may underlie increased risk. Metals alter DNA methylation, yet little is known about their individual and combined impact on epigenetic age acceleration. Our objective was to investigate the associations of metals on several DNA methylation-based aging measures in the Strong Heart Study (SHS) cohort.
methodsBlood DNA methylation data from 2,301 SHS participants was used to calculate age acceleration of epigenetic clocks (PhenoAge, GrimAge, DunedinPACE, Hannum, Horvath). Urinary metals [arsenic (As), cadmium (Cd), tungsten (W), zinc (Zn), selenium (Se), molybdenum (Mo)] were creatinine-adjusted and categorized into quartiles. We examined associations of individual metals through linear regression models and used Bayesian Kernel Machine Regression (BKMR) for the impact of the total metal mixture on epigenetic age acceleration.
resultsThe mixture of nonessential metals (W, As, Cd) was associated with greater GrimAge acceleration and DunedinPACE, while the essential metal mixture (Se, Zn, Mo) was associated with lower epigenetic age acceleration. Cd was associated with increased epigenetic age acceleration across all clocks and BKMR analysis suggested nonlinear associations between Se and DunedinPACE, GrimAge, and PhenoAge acceleration. No interactions between individual metals were observed. The associations between Cd, Zn, and epigenetic age acceleration were greater in never smokers in comparison to current/former smokers.
conclusionNonessential metals were positively associated with greater epigenetic age acceleration, with strongest associations observed between Cd and DunedinPACE and GrimAge acceleration. In contrast, essential metals were associated with lower epigenetic aging. Examining the influence of metal mixtures on epigenetic age acceleration can provide insight into metals and aging-related diseases.
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Registered trials
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