Evidence map›Paper›PMID 37364280›Full record

Trial reportAmerican journal of respiratory and critical care medicine2023

Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial.

Ari Moskowitz, Katherine M Berg, Anne V Grossestreuer, Lakshman Balaji, Xiaowen Liu, Michael N Cocchi, Maureen Chase, Michelle Ng Gong, Jonathan Gong, Samir M Parikh and 3 more

Open access · greenAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Serum vitamins andFrontiers in immunology · 2026
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Challenges of Using and Measuring Thiamine in Critical Care.American journal of respiratory and critical care medicine · 2024
    Article
  13. Reply to MuminAmerican journal of respiratory and critical care medicine · 2024
    Article
  14. Article
  15. Thiamine for Septic Shock: Take Your Vitamins?American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Ari MoskowitzDivision of Critical Care Medicine, Montefiore Medical Center, The Bronx, New York.
Katherine M BergCenter for Resuscitation Science.
Anne V GrossestreuerCenter for Resuscitation Science.
Lakshman BalajiCenter for Resuscitation Science.
Xiaowen LiuCenter for Resuscitation Science.
Michael N CocchiCenter for Resuscitation Science.
Maureen ChaseCenter for Resuscitation Science.
Michelle Ng GongDivision of Critical Care Medicine, Montefiore Medical Center, The Bronx, New York.
Jonathan GongDepartment of Emergency Medicine, Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York; and.
Samir M ParikhDivision of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas.
Long NgoDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Noa BerlinCenter for Resuscitation Science.
Michael W DonninoCenter for Resuscitation Science.
Resuscitation Council · GBBeth Israel Deaconess Medical Center · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USSleepMed · USThe Bronx Defenders · USThe University of Texas Southwestern Medical Center · US

Funding

Tie2-driven vascular control in critical illnessR35HL139424 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PARIKH, SAMIR M · 2018 to 2024
$6.4M
Mitochondrial Biogenesis in Kidney DiseaseR01DK095072 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Samir M Parikh · 2012 to 2026
$5.3M
Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP)R01DK130929 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael William Donnino · 2022 to 2026
$1.9M
Thaimine as an adjunct metabolic resuscitator in cardiac arrestK24HL127101 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DONNINO, MICHAEL WILLIAM · 2015 to 2024
$1.2M
Thiamine as a Renal Protective Agent in Septic ShockK23GM128005 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSKOWITZ, ARI · 2018 to 2021
$761k
NHLBI NIH HHS K24 HL127101NHLBI NIH HHS K24HL127101NHLBI NIH HHS R35 HL139424NIDDK NIH HHS R01 DK095072NIDDK NIH HHS R01 DK130929NIGMS NIH HHS K23 GM128005NIGMS NIH HHS K23GM128005
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Kidney InjuryShock, SepticCreatinineHumansKidneyThiamineCreatinineThiaminekidney injurysepsisshockthiamine

Identifiers

PMID37364280
PMCPMC10492240
OpenAlexW4382046515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.