Evidence map›Paper›PMID 37364114›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Structural evolution of an immune evasion determinant shapes pathogen host tropism.

Ashley L Marcinkiewicz, Kalvis Brangulis, Alan P Dupuis, Thomas M Hart, Maxime Zamba-Campero, Tristan A Nowak, Jessica L Stout, Inara Akopjana, Andris Kazaks, Janis Bogans and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hitchhiker's Guide toJournal of bacteriology · 2024
    Review
  15. Comparative reservoir competence ofApplied and environmental microbiology · 2024
    Article
  16. Article
  17. Review
  18. Differential Resistance ofPathogens (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Ashley L MarcinkiewiczNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.ORCID 0000-0003-1417-5699
Kalvis BrangulisLatvian Biomedical Research and Study Centre, Riga LV-1067, Latvia.ORCID 0000-0003-0757-7462
Alan P DupuisNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.ORCID 0000-0003-0703-9250
Thomas M HartNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.ORCID 0000-0001-5949-9932
Maxime Zamba-CamperoNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.
Tristan A NowakNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.
Jessica L StoutNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.
Inara AkopjanaLatvian Biomedical Research and Study Centre, Riga LV-1067, Latvia.
Andris KazaksLatvian Biomedical Research and Study Centre, Riga LV-1067, Latvia.
Janis BogansLatvian Biomedical Research and Study Centre, Riga LV-1067, Latvia.
Alexander T CiotaNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.ORCID 0000-0001-6589-4728
Peter KraiczyInstitute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Goethe University Frankfurt, Frankfurt 60596, Germany.
Sergios-Orestis KolokotronisDepartment of Epidemiology and Biostatistics, School of Public Health, Brooklyn, NY 11203-2098.ORCID 0000-0003-3309-8465
Yi-Pin LinNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, NY 12208.ORCID 0000-0002-5240-2031
Albany State University · USLatvian Biomedical Research and Study Centre · LVNew York State Department of Health · USGoethe University Frankfurt · DEState University of New York · US

Funding

IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
Early Host Responses During Co-Infection of Tick-Borne PathogensR21AI146381 · NIAID · ALBANY MEDICAL COLLEGE · PI LIN, YI-PIN, MACNAMARA, KATHERINE C. · 2020 to 2021
$466k
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
NHLBI NIH HHS T32 HL007974NIAID NIH HHS R21 AI144891NIAID NIH HHS R21 AI146381
6 · The paper itself

Abstract

Modern infectious disease outbreaks often involve changes in host tropism, the preferential adaptation of pathogens to specific hosts. The Lyme disease-causing bacterium

Indexed as

Borrelia burgdorferiLyme DiseaseAnimalsBacterial ProteinsComplement Factor HComplement System ProteinsHumansImmune EvasionMembrane ProteinsPhylogenyViral TropismBacterial ProteinsComplement Factor HComplement System ProteinsMembrane ProteinscomplementCspZfactor Hhost tropismLyme disease

Identifiers

PMID37364114
PMCPMC10319004
OpenAlexW4382047587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.