ArticleJournal of the American Medical Informatics Association : JAMIA2023
Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory.
Article in Journal of the American Medical Informatics Association : JAMIA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review.JMIR mental health · 2026Pooled it
- Incidence of occupational HIV seroconversion among healthcare workers: a systematic review and meta-analysis.BMC health services research · 2026Pooled it
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- Assessment of real-world evidence research competencies in federated research networks: a maternal health fellowship program evaluation.JAMIA open · 2026Article
- Exploratory associations between co-occurring opioid and alcohol use disorders and GIP/GLP-1 receptor agonist treatment.Communications medicine · 2026Article
- Information Distortion in Electronic Health Records: A Concept Analysis.Journal of advanced nursing · 2026Review
- Data-driven prioritization of high-risk individuals for weight loss interventions.Nature medicine · 2026Article
- Beyond Missingness: Systematizing Methods for Comprehensive Data Fitness Assessment in Clinical Research.Journal of medical Internet research · 2026Article
- An operational target trial emulation framework for causal inference using electronic health record data.NPJ digital medicine · 2026Review
- Understanding and Addressing Bias in Artificial Intelligence Systems: A Primer for the Emergency Medicine Physician.Journal of the American College of Emergency Physicians open · 2026Article
- Recruitment Strategies to Prevent Fraudulent Virtual Enrollment While Respecting Privacy in Vulnerable Populations.Qualitative health research · 2025Article
- Improving Representation of Underserved Populations in Cardiovascular Research.Journal of the American Heart Association · 2025Review
- The Lifecycle of Electronic Health Record Data in HIV-Related Big Data Studies: Qualitative Study of Bias Instances and Potential Opportunities for Minimization.Journal of medical Internet research · 2025Article
- Early Warning of Infectious Disease Outbreaks Using Social Media and Digital Data: A Scoping Review.International journal of environmental research and public health · 2025Article
- LADDER: Language-Driven Slice Discovery and Error Rectification in Vision Classifiers.Findings of ACL. ACL · 2025Article
- Critical Roles for Modeling and Simulation and Real-World Evidence to Inform Challenges in Clinical Trial Diversity Planning.Clinical and translational science · 2025Review
- Monitoring in pragmatic trials lessons from the NIH pragmatic trials collaboratory.Contemporary clinical trials · 2025Article
- Analyzing Physician In Basket Burden and Efficiency Using K-Means Clustering.Applied clinical informatics · 2025Article
- Investigating Primary Care Indications to Improve the Quality of Electronic Health Record Data in Target Trial Emulation for Dementia.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing current population health problems, and their use of electronic health record (EHR) systems promises efficiencies that will increase the speed and volume of relevant and generalizable research. However, as the number of ePCTs using EHR-derived data grows, so does the risk that research will become more vulnerable to biases due to differences in data capture and access to care for different subsets of the population, thereby propagating inequities in health and the healthcare system. We identify 3 challenges-incomplete and variable capture of data on social determinants of health, lack of representation of vulnerable populations that do not access or receive treatment, and data loss due to variable use of technology-that exacerbate bias when working with EHR data and offer recommendations and examples of ways to actively mitigate bias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.