ArticleJournal of the American Chemical Society2023
Ultrafast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids.
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Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
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33 citing papers in PubMed, 54 citations in OpenAlex.
- Site-Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids.Angewandte Chemie (International ed. in English) · 2026Review
- Binding Affinity Determines the Success of Endogenous CuThe journal of physical chemistry letters · 2026Article
- A dynamic duo: Copper metalloregulators and continuous-wave electron spin resonance spectroscopy.Biophysical reports · 2026Review
- Nitroxide spin, non-canonical amino acids and SDSL-EPR spectroscopy: a winning combination for protein dynamics studies.European biophysics journal : EBJ · 2026Article
- Scalable Flow Synthesis of Genetically Encodable Tetrazine Amino Acids.Organic process research & development · 2026Article
- A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery.Molecular therapy. Oncology · 2025Article
- Recent advances in quantifying protein conformational ensembles with dipolar EPR spectroscopy.Current opinion in structural biology · 2025Review
- Tuning Encodable Tetrazine Chemistry for Site-Specific Protein Bioorthogonal Ligations.Angewandte Chemie (International ed. in English) · 2025Article
- Quantitative Protein Labeling in Live Cells by Controlling the Redox State of Encoded Tetrazines.Journal of the American Chemical Society · 2025Article
- Small Protein Domains as Potential Spin Labels for In Vitro, Cellular, and Light-Induced Dipolar EPR Spectroscopy.Journal of the American Chemical Society · 2025Article
- Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy.Nature communications · 2025Article
- Protein Modeling with DEER Spectroscopy.Annual review of biophysics · 2025Review
- Towards Metabolic Organic Radical Contrast Agents (mORCAs) for Magnetic Resonance Imaging.Molecules (Basel, Switzerland) · 2025Article
- Genetic Code Expansion: Recent Developments and Emerging Applications.Chemical reviews · 2025Review
- Endogenous Cu(II) Labeling for Distance Measurements on Proteins by EPR.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Noncanonical Amino Acid Tools and Their Application to Membrane Protein Studies.Chemical reviews · 2024Review
- Investigating Protein Degradability through Site-Specific Ubiquitin Ligase Recruitment.bioRxiv : the preprint server for biology · 2024Article
- Genetic Code Expansion for Mechanistic Studies in Ion Channels: An (Un)natural Union of Chemistry and Biology.Chemical reviews · 2024Review
- Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming.Chemical reviews · 2024Review
- Cracking the Code: Reprogramming the Genetic Script in Prokaryotes and Eukaryotes to Harness the Power of Noncanonical Amino Acids.Chemical reviews · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Subhashis JanaDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.
Eric G B EvansDepartment of Chemistry, University of Washington, Seattle, Washington 98195, United States.
Hyo Sang JangDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-0460-9924
Shuyang ZhangDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.
Hui ZhangDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.
Andrzej RajcaDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.ORCID 0000-0002-8856-1536
Sharona E GordonDepartment of Physiology & Biophysics, University of Washington, Seattle, Washington 98195, United States.
William N ZagottaDepartment of Physiology & Biophysics, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0002-7631-8168
Stefan StollDepartment of Chemistry, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0003-4255-9550
Ryan A MehlDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2932-4941
University of Washington · USOregon State University · USUniversity of Nebraska–Lincoln · US
Funding
GATING MECHANISMS OF RETINAL ROD CGMP-ACTIVATED CHANNELSR01EY010329 · NEI · UNIVERSITY OF WASHINGTON · PI ZAGOTTA, WILLIAM N · 1994 to 2023
$7.7MThe GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical ResearchRM1GM144227 · NIGMS · OREGON STATE UNIVERSITY · PI RYAN A MEHL · 2022 to 2026
$6.2MVISUAL SCIENCES TRAINING PROGRAMT32EY007031 · NEI · UNIVERSITY OF WASHINGTON · PI Wyeth Daniel Bair, Anitha Pasupathy · 1985 to 2026
$6.1MConformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion ChannelsR35GM145225 · NIGMS · UNIVERSITY OF WASHINGTON · PI Sharona E Gordon · 2022 to 2026
$3.4MNew Nitroxide Spin Labels for Distance Measurements in Biological SystemsR01GM124310 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI RAJCA, ANDRZEJ · 2017 to 2020
$1.7MStructural mechanisms for gating of bacterial cyclic nucleotide-gated ion channelsR01GM127325 · NIGMS · UNIVERSITY OF WASHINGTON · PI ZAGOTTA, WILLIAM N · 2018 to 2021
$1.6MEquipment Supplement: Analysis tools for quantifying protein conformational landscapes using DEER spectroscopyR01GM125753 · NIGMS · UNIVERSITY OF WASHINGTON · PI STOLL, STEFAN · 2019 to 2022
$1.3MDevelopment of an improved core technology for efficient genetic code expansion in biomedical researchR01GM131168 · NIGMS · OREGON STATE UNIVERSITY · PI MEHL, RYAN A · 2019 to 2021
$1.1MHigh-sensitivity upgrade of DEER/EPR spectrometerS10OD021557 · OD · UNIVERSITY OF WASHINGTON · PI STOLL, STEFAN · 2017 to 2017
$495kIon Mobility Time-of-flight Mass Spectrometry SystemS10RR025628 · NCRR · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S, STEVENS, JAN FREDERIK · 2009 to 2009
$440kNCRR NIH HHS S10 RR025628NEI NIH HHS R01 EY010329NEI NIH HHS T32 EY007031NIGMS NIH HHS R01 GM124310NIGMS NIH HHS R01 GM125753NIGMS NIH HHS R01 GM127325NIGMS NIH HHS R01 GM131168NIGMS NIH HHS R35 GM145225NIGMS NIH HHS RM1 GM144227NIH HHS S10 OD021557
Abstract
Site-directed spin-labeling (SDSL)─in combination with double electron-electron resonance (DEER) spectroscopy─has emerged as a powerful technique for determining both the structural states and the conformational equilibria of biomacromolecules. DEER combined with
Indexed as
Amino AcidsHeterocyclic CompoundsAnimalsElectron Spin Resonance SpectroscopyHEK293 CellsHumansMammalsNitrogen OxidesProteinsSpin LabelsAmino AcidsHeterocyclic CompoundsNitrogen OxidesnitroxylProteinsSpin Labels
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