Evidence map›Paper›PMID 37363987›Full record

ArticleFEBS open bio2023

Chrysin 7-O-β-d-glucopyranoside increases hepatic low-density lipoprotein receptor expression through AMP-activated protein kinase activation.

Naoki Kaname, Takahiro Fujimaki, Shotaro Horikoshi, Kaito Fujimura, Manami Kodaka, Shinnosuke Wakamori, Ryo Katsuta, Ken Ishigami, Tsukasa Suzuki, Yuji Yamamoto and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Naoki KanameDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Takahiro FujimakiDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Shotaro HorikoshiDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Kaito FujimuraDepartment of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Japan.
Manami KodakaDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Shinnosuke WakamoriDepartment of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Japan.
Ryo KatsutaDepartment of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Japan.
Ken IshigamiDepartment of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Japan.
Tsukasa SuzukiDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Yuji YamamotoDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.
Jun InoueDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Japan.ORCID 0000-0002-8987-3494
Tokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated plasma low-density lipoprotein (LDL) cholesterol level is a risk factor for developing atherosclerosis. Increased LDL receptor (LDLR) expression is expected to reduce the risk of atherosclerotic disease since hepatic LDLR is essential for clearing plasma LDL cholesterol. Here, we screened human LDLR promoter effectors and observed that extracts from peduncles of sweet cherry (Prunus avium) 'Sato-Nishiki' induce LDLR gene promoter activity. We used several analytical and chemical methods to show that chrysin 7-O-β-d-glucopyranoside (chrysin-7G) is one of the compounds that stimulate LDLR gene promoter activity in cherry peduncle extracts. Furthermore, synthetic chrysin-7G increased the expression and activity of LDLR. The chrysin-7G-mediated increase in LDLR expression and activity was completely abolished by treatment with an AMP-activated protein kinase (AMPK) inhibitor, compound C. These results indicate that chrysin-7G increases LDLR expression through AMPK activation and may be a useful compound that can be recycled from waste parts of agricultural products.

Indexed as

AMP-Activated Protein KinasesAtherosclerosisFlavonoidsHumansLipoproteins, LDLLiverReceptors, LDLAMP-Activated Protein KinaseschrysinFlavonoidsLipoproteins, LDLReceptors, LDLAMPKchrysinLDL receptorpolyphenolssweet cherry

Identifiers

PMID37363987
PMCPMC10392065
OpenAlexW4382138435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.