Evidence map›Paper›PMID 37363741›Full record

ArticleCurrent research in toxicology2023

Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across.

Shengde Wu, George Daston, Jane Rose, Karen Blackburn, Joan Fisher, Allison Reis, Bastian Selman, Jorge Naciff

Abstract read
In one paragraph

Article in Current research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengde WuCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
George DastonCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Jane RoseCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Karen BlackburnCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Joan FisherCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Allison ReisCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Bastian SelmanCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.
Jorge NaciffCentral Product Safety Department, The Procter & Gamble Company, 8700 Mason Montgomery Rd, Cincinnati, OH 45040 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver is the most common target organ in toxicology studies. The development of chemical structural alerts for identifying hepatotoxicity will play an important role in

Indexed as

Chemical categoriesHepatotoxicityHepatotoxicity decision treeMode of actionSAR read-across

Identifiers

PMID37363741
PMCPMC10285556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.