ReviewAdvances in laboratory medicine2021
Single-embryo transfer: a key strategy to reduce the risk for multiple pregnancy in assisted human reproduction.
Review in Advances in laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Economic evaluation of embryo transfer strategies in in vitro fertilization (IVF): a systematic review.Journal of health, population, and nutrition · 2025Pooled it
- Twin pregnancy and postpartum haemorrhage: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Day 3 embryo quality predicts clinical pregnancy and live birth rates following single frozen-thawed poor-quality blastocyst transfer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Comprehensive genetic screening of in vitro fertilized embryos using preimplantation genetic testing for monogenic gene disorders via the Sanger sequencing technique.Molecular biology reports · 2025Article
- Elective single morula transfer achieved better clinical outcomes than two cleavage embryos transfer in fresh IVF-ET cycles.BMC pregnancy and childbirth · 2025Article
- The Impact of Conception Method, Chorionicity, Amnionicity, Fetal Growth Types, and Birth Order on the Postnatal Status of Twins Born Vaginally and by Cesarean Section: A Retrospective Analysis of Data from a University Centre of Obstetrics and Gynecology (1990-2017).Journal of clinical medicine · 2025Article
- Morphometric Blastocyst Assessment: A Retrospective Study Examining the Relationship Between Blastocyst Diameter and Area and Pregnancy Outcomes in Assisted Reproduction Technology Cycles.Journal of clinical medicine · 2025Article
- Cellular mechanisms of monozygotic twinning: clues from assisted reproduction.Human reproduction update · 2024Review
- The association between female age and pregnancy outcomes in patients receiving first elective single embryo transfer cycle: a retrospective cohort study.Scientific reports · 2024Article
- Preimplantation genetic testing for aneuploidy (PGT-A)-a single-center experience.Journal of assisted reproduction and genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the early days of assisted reproductive technology (ART), the main target was achieving gestation. Success rates were low, and multiple embryo transfers became common practice, with multiple pregnancies being 20 times higher than in natural conception. Multiple pregnancy is associated with a higher risk of complications for the mother and the baby than a singleton pregnancy. Added to healthcare costs, multiple pregnancy also involves other costs and psychosocial risks, with a high social and health costs. At present, success rates of assisted human reproduction (AHR) have improved dramatically, partially due to advances in laboratory techniques such as culture of blastocyst-stage embryos and vitrification. Additionally, there is a wide range of counseling, health and economic policies that have demonstrated being effective in increasing single-embryo transfer (SET) practices and reducing multiple pregnancies, which ensures satisfactory success rates. Therefore, single-embryo transfer emerges as the approach of choice for AHR to result in a full-term healthy newborn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.