ArticleOne health (Amsterdam, Netherlands)2023
The significance of mosquito saliva in arbovirus transmission and pathogenesis in the vertebrate host.
Article in One health (Amsterdam, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
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- Chromosome-scale genome of Culicoides brevitarsis provides a resource for comparative and vector biology studies.Parasites & vectors · 2026Article
- From promise to pitfalls: immunological lessons from dengue vaccines and their implications.NPJ vaccines · 2026Review
- NS5-targeting nucleoside analogs inhibit dengue virus and other flaviviruses.PLoS pathogens · 2026Article
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- Emerging and re-emerging vector-borne and other zoonotic RNA viruses: pathogenesis, climate-driven dynamics, and strategies for global control.Frontiers in microbiology · 2026Review
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- Effect of mosquito saliva from distinct species on human dermal endothelial cell functionEmerging microbes & infections · 2025Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- Extrapolation and comparison of West Nile virus- and Usutu virus-associated neurological diseases in humans: linking pathology to clinical symptoms.Clinical microbiology reviews · 2025Review
- In vitro and in vivo characterization of a novel West Nile virus lineage 2 strain.Npj viruses · 2024Article
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- Revisiting the paradigm of anhematophagy in male mosquitoes.bioRxiv : the preprint server for biology · 2024Article
- Characterization of bacteria expectorated during forced salivation of the Phlebotomus papatasi: A neglected component of sand fly infectious inoculums.PLoS neglected tropical diseases · 2024Article
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- Mosquito Salivary Antigens and Their Relationship to Dengue andPathogens (Basel, Switzerland) · 2024Article
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- A One Health approach to predict, monitor and prevent arbovirus infections, an extensive case study from the Netherlands - Editorial.One health (Amsterdam, Netherlands) · 2023Article
- Host Derivation of Sindbis Virus Influences Mammalian Type I Interferon Response to Infection.Viruses · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to changes in climate, numerous mosquito species are continuously extending their geographical distributions, posing potential new public health threats as arbovirus infections emerge in these new areas. During probing and feeding on the vertebrate host, a mosquito can inject both arbovirus and saliva into the skin of the host. The presence of mosquito saliva in the host skin during arbovirus transmission contributes to high viral titers in the skin, enhanced viremia, and rapid dissemination of the virus to target organs. This enhanced phenotype effectuated by the presence of mosquito saliva in the skin can be partly ascribed to a polarization of the local immune balance towards a Th2 response, an increased permeability of the dermal endothelium, and the influx of virus-susceptible immune cells to the bite site. However, the complete identification and characterization of immunomodulatory salivary proteins from different mosquito species and the mechanisms by which these salivary proteins exert their effects synergistically or antagonistically remains to be further explored. Moreover, the effect of new virus-vector combinations on the outcome of arbovirus infection in a new host is limited. Here, we review the immunomodulatory effects of mosquito saliva in the skin and the proposed mechanisms by which mosquito saliva enhances arbovirus pathogenesis in the vertebrate host, and discuss potential differences between
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