Evidence map›Paper›PMID 37363234›Full record

ArticleOne health (Amsterdam, Netherlands)2023

H10Nx avian influenza viruses detected in wild birds in China pose potential threat to mammals.

Xinru Lv, Jingman Tian, Xiang Li, Xiaoli Bai, Yi Li, Minghui Li, Qing An, Xingdong Song, Yu Xu, Heting Sun and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in One health (Amsterdam, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Xinru LvCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Jingman TianState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
Xiang LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Xiaoli BaiState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
Yi LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Minghui LiState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
Qing AnCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Xingdong SongCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yu XuBiological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
Heting SunBiological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
Peng PengBiological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
Siyuan QinBiological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
Zhenliang ZhaoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Rongxiu QinCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Qiuzi XuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Fengyi QuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Meixi WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Hua LuoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Zhen ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Xiangwei ZengCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yajun WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Zhijun HouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Xiaoyu ZhouSiberian Tiger Park, Harbin 150028, China.
Yulong WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yanbing LiState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
Hongliang ChaiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic avian species worldwide and have occasionally crossed the species barrier to mammalian hosts. Fatal human cases of H10N8 infections and the recent detection of human H10N3 infections have drawn widespread public attention. In this study, 25 H10Nx viruses were isolated from wild waterfowl in China during a long-term surveillance of AIVs. We conducted phylogenetic and phylogeographic studies of the hemagglutinin (HA) genes of global H10 viruses to determine the spatiotemporal patterns of spread and the roles of different hosts in viral transmission. We found the pattern of AIV transmission from wild birds to poultry to humans, and Anatidae have acted as the seeding population in the spread of the virus. Phylogenetic incongruence indicated complex reassortment events and our isolates were divided into eight genotypes (G1-8). We also found that the HA genes of the G8 viruses belonged to the North American lineage, indicating that intercontinental gene flow has occurred. Their receptor-binding specificity showed that the G1/4/5/6/7/8 viruses bind to both human-type α2,6-linked sialic acid receptors and avian-type α2,3-linked sialic acid receptors. Mouse studies indicated that the H10Nx isolates replicated efficiently in the respiratory system without preadaptation, but showed low pathogenicity in mice. The H10Nx isolates showed no (G2/4/7) or low pathogenicity (G1/3/5/6/8) in chickens, and the G6 and G8 viruses could be transmitted to chickens through direct contact. The asymptomatic shedding of these wild-bird-origin H10Nx isolates in chickens and their good adaptation in mice should increase the ease of their transmission to humans, and they therefore pose a threat to public health. Our findings demonstrate a further understanding of wild bird-origin H10 viruses and provide information for the continuous surveillance of H10 subtype viruses.

Indexed as

Avian influenza virusH10 subtypePathogenicityPhylogeographyWild birds

Identifiers

PMID37363234
PMCPMC10288057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.