ArticleOpen forum infectious diseases2023
Cefazolin vs Second-line Antibiotics for Surgical Site Infection Prevention After Total Joint Arthroplasty Among Patients With a Beta-lactam Allergy.
Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Improving surgical antimicrobial prophylaxis in patients with a penicillin allergy label: a quality improvement study.BMJ open quality · 2026Article
- Antibiotics in Hand Surgery: Guidelines and Review.Journal of hand surgery global online · 2026Review
- β-Lactam vs Non-β-Lactam Prophylaxis in Elective Colorectal Surgery.JAMA network open · 2026Observational
- Perioperative cefazolin prophylaxis in patients with β-lactam allergy: a quality improvement project.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Cefazolin prophylaxis is associated with lower surgical site infection risk than vancomycin following elective spine surgery.North American Spine Society journal · 2026Article
- Cefazolin as an alternative in patients with a history of penicillin or β-lactam antibiotic allergy: A case overview.Allergologie select · 2026Article
- Current status and challenges in the assessment of antibiotic allergy information in electronic health records: a retrospective observational study of perioperative patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Surgical Site Infection Prevention Research: A Bibliometric Analysis of the Top 50 Highly Cited Articles.Cureus · 2026Review
- Optimizing perioperative antibiotic prophylaxis: a prospective cohort study on cefazolin utilization in surgical patients with penicillin allergy labels.Perioperative medicine (London, England) · 2025Article
- Non-β-Lactam Antibiotic Use, β-Lactam Allergy, and Surgical Site Infections.JAMA surgery · 2025Article
- [Antibiotic stewardship-an update : Ongoing development of an initiative].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Antibiotic Prophylaxis in Instrumented Lumbar Spine Surgery: Cefazolin Outperforms Clindamycin Regardless of Duration.Antibiotics (Basel, Switzerland) · 2025Article
- Non-cefazolin antibiotic prophylaxis is associated with increased rates of acute infectious, medical, and surgical complications following primary total shoulder arthroplasty: a database study.JSES international · 2025Article
- Cefazolin versus alternative antibiotics for perioperative prophylaxis in patients labeled as cephalosporin allergic.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Early and delayed periprosthetic joint infection in robot-assisted total knee arthroplasty: a multicenter study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Examining cefazolin utilization and perioperative anaphylaxis in patients with and without a penicillin allergy label: A cross-sectional study.Journal of clinical anesthesia · 2024Article
- Antibiotic Stewardship in Surgical Departments.Antibiotics (Basel, Switzerland) · 2024Review
- Management of Penicillin Allergy in the Perioperative Setting.Antibiotics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cefazolin is a first-line agent for prevention of surgical site infections (SSIs) after total joint arthroplasty. Patients labeled allergic to beta-lactam antibiotics frequently receive clindamycin or vancomycin perioperatively due to the perceived risk of a hypersensitivity reaction after exposure to cefazolin. Methods: This single-system retrospective review included patients labeled allergic to penicillin or cephalosporin antibiotics who underwent a primary total hip and/or knee arthroplasty between January 2020 and July 2021. A detailed chart review was performed to compare the frequency of SSI within 90 days of surgery and interoperative hypersensitivity reactions (HSRs) between patients receiving cefazolin and patients receiving clindamycin and/or vancomycin. Results: A total of 1128 hip and/or knee arthroplasties from 1047 patients were included in the analysis (cefazolin n = 809, clindamycin/vancomycin n = 319). More patients in the clindamycin and/or vancomycin group had a history of cephalosporin allergy and allergic reactions with immediate symptoms. There were fewer SSIs in the cefazolin group compared with the clindamycin and/or vancomycin group (0.9% vs 3.8%; Conclusions: The use of cefazolin as a perioperative antibiotic for infection prophylaxis in total joint arthroplasty in patients labeled beta-lactam allergic is associated with decreased postoperative SSI without an increase in interoperative HSR.
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