Evidence map›Paper›PMID 37362410›Full record

ArticleAdvances in laboratory medicine2021

Real-world assessment of Fluorecare SARS-CoV-2 Spike Protein Test Kit.

Gian Luca Salvagno, Gianluca Gianfilippi, Laura Pighi, Simone De Nitto, Brandon M Henry, Giuseppe Lippi

Abstract read
In one paragraph

Article in Advances in laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gian Luca SalvagnoSection of Clinical Biochemistry, University of Verona, Verona, Italy.
Gianluca GianfilippiMedical Direction, Pederzoli Hospital, Peschiera del Garda, Italy.
Laura PighiSection of Clinical Biochemistry, University of Verona, Verona, Italy.
Simone De NittoSection of Clinical Biochemistry, University of Verona, Verona, Italy.
Brandon M HenryThe Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Giuseppe LippiSection of Clinical Biochemistry, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-9523-9054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Since commercial SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antigen rapid detection tests (Ag-RDTs) display broad diagnostic efficiency, this study aimed to evaluate the clinical performance of Fluorecare SARS-CoV-2 Spike Protein Test Kit in a real-life scenario. Methods: The study population consisted of a series of patients undergoing SARS-Cov-2 diagnostic testing at Pederzoli Hospital of Peschiera del Garda (Verona, Italy). A nasopharyngeal swab was collected upon hospital admission and assayed with molecular (Altona Diagnostics RealStar Results: The study population consisted of 354 patients (mean age, 47 ± 20 years; 195 women, 55.1%), 223 (65.8%) positive at molecular testing. A significant correlation was found between Fluorecare SARS-CoV-2 Spike Protein Test Kit and Altona (both Conclusions: The modest sensitivity and negative predictive value of Fluorecare SARS-CoV-2 Spike Protein Test Kit makes unadvisable to use this assay as surrogate of molecular testing for definitively diagnosing SARS-CoV-2 infection, though its suitable sensitivity at high viral load could make it a reliable screening test for patients with higher infective potential.

Indexed as

COVID-19diagnosisimmunoassaylaboratory medicineSARS-CoV-2

Identifiers

PMID37362410
PMCPMC10197504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.