Acute and developmental toxicity of embelin isolated from

Zelalem Animaw, Kaleab Asres, Abiy Abebe, Samson Taye, Girma Seyoum

Open access · goldAbstract read

In one paragraph

Article in Toxicology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.8field-weighted citation impact, top 17% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zelalem AnimawDepartment of Anatomy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Kaleab AsresDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Abiy AbebeTraditional and Modern Drug Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Samson TayeTraditional and Modern Drug Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Girma SeyoumDepartment of Anatomy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Addis Ababa University · ETEthiopian Public Health Institute · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Embelin is a hydroxybenzoquinone constituent of the Embelia species that has anti-disease properties. However, its toxicity, particularly the Materials and Methods: Results: Conclusion: Embelin is predicted to have a high probability of immunotoxicity potential and affect drug metabolism by inhibiting CYP2D6. In addition, it affects food intake, weight gain, and the number of implantations in pregnant rats. Therefore, it is highly recommended not to take embelin and embelin-rich plants during pregnancy. Further

Indexed as

Developmental toxicityEmbelia SchimperiEmbelinin silicoToxicity

Identifiers

PMID37362226

DOI10.1016/j.toxrep.2023.06.006

PMCPMC10285041

OpenAlexW4380148777

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.