Evidence map›Paper›PMID 37361483›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2023

Psychophysiologic Symptom Relief Therapy (PSRT) for Post-acute Sequelae of COVID-19.

Michael Donnino, Patricia Howard, Shivani Mehta, Jeremy Silverman, Maria J Cabrera, Jolin B Yamin, Lakshman Balaji, Katherine M Berg, Stanley Heydrick, Robert Edwards and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04854772 (Mind Body Intervention for COVID-19 Long Haul Syndrome), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04854772 nacompletednot on this map

Mind Body Intervention for COVID-19 Long Haul Syndrome

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2021 to 2022Enrolled23ConditionsCOVID-19 Long Haul SyndromeArmsMind Body Syndrome Therapy for Long Covid
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. 'I Want Everyone to Have It, and Everyone to Be on It': A Feasibility Study of the Transforming Long Covid Intervention.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  3. Article
  4. 'The Second Arrow': A Collaborative Autoethnographic Exploration of What Can Be Learned From One Long COVID Journey.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael DonninoDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Patricia HowardDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Shivani MehtaDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Jeremy SilvermanDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Maria J CabreraDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Jolin B YaminDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Lakshman BalajiDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Katherine M BergDivision of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Stanley HeydrickDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Robert EdwardsDepartment of Anesthesiology, Pain Management Center, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill MA, USA.
Anne V GrossestreuerDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

Training Program in Resuscitation ScienceT32HL155020 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael William Donnino, Robert Yeh · 2021 to 2026
$2.6M
NHLBI NIH HHS T32 HL155020
6 · The paper itself

Abstract

Objective: To determine if psychophysiologic symptom relief therapy (PSRT) will reduce symptom burden in patients suffering from post-acute sequelae of COVID-19 (PASC) who had mild/moderate acute COVID-19 disease without objective evidence of organ injury. Patients and Methods: Twenty-three adults under the age of 60 with PASC for at least 12 weeks following COVID-19 infection were enrolled in an interventional cohort study conducted via virtual platform between May 18, 2021 and August 7, 2022. Participants received PSRT during a 13 week (approximately 44 hour) course. Participants were administered validated questionnaires at baseline and at 4, 8, and 13 weeks. The primary outcome was change in somatic symptoms from baseline, measured using the Somatic Symptom Scale-8 (SSS-8), at 13 weeks. Results: The median duration of symptoms prior to joining the study was 267 days (IQR: 144, 460). The mean SSS-8 score of the cohort decreased from baseline by 8.5 (95% CI: 5.7-11.4), 9.4 (95% CI: 6.9-11.9), and 10.9 (95% CI: 8.3-13.5) at 4, 8, and 13 weeks respectively (all p<.001). Participants also experienced statistically significant improvements across other secondary outcomes including changes in dyspnea, fatigue, and pain (all p<.001). Conclusion: PSRT may effectively decrease symptom burden in patients suffering from PASC without evidence of organ injury. The study was registered on clinicaltrials.gov (NCT04854772).

Identifiers

PMID37361483
PMCPMC10196153
OpenAlexW4377096884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.