Evidence map›Paper›PMID 37361352›Full record

ArticleMolecular therapy. Methods & clinical development2023

Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6.

Russell W Mellen, Kaitlyn R Calabro, K Tyler McCullough, Sean M Crosson, Alejandro de la Cova, Diego Fajardo, Emily Xu, Sanford L Boye, Shannon E Boye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Russell W MellenDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Kaitlyn R CalabroDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
K Tyler McCulloughDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Sean M CrossonDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Alejandro de la CovaDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Diego FajardoDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Emily XuDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Sanford L BoyePowell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Shannon E BoyeDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
University of Florida · US

Funding

Engineering AAV for safe and efficient gene delivery to the human retinaR01EY024280 · NEI · UNIVERSITY OF FLORIDA · PI Shannon Elizabeth Boye · 2014 to 2026
$7.5M
RESEARCH TRAINING IN VISION SCIENCET32EY007132 · NEI · UNIVERSITY OF FLORIDA · PI W CLAY SMITH · 1991 to 2026
$3.8M
DEVELOPMENT OF AAV-CRISPR/CAS9-BASED THERAPIES FOR CONE ROD DYSTROPHYR01EY028968 · NEI · UNIVERSITY OF FLORIDA · PI BOYE, SHANNON ELIZABETH, GAMLIN, PAUL DOUGLAS · 2019 to 2022
$2.2M
Core Equipment for Assessment of Ocular Disease in Animal ModelsS10OD028476 · OD · UNIVERSITY OF FLORIDA · PI SMITH, W CLAY · 2020 to 2020
$348k
NEI NIH HHS R01 EY024280NEI NIH HHS R01 EY028968NEI NIH HHS T32 EY007132NIH HHS S10 OD028476
6 · The paper itself

Abstract

Cone-rod dystrophy 6 (CORD6) is caused by gain-of-function mutations in the

Indexed as

AAVadeno-associated viruscone-rod dystrophyCORD6gene therapyGUCY2Dinherited retinal diseaseophthalmologyretina

Identifiers

PMID37361352
PMCPMC10285452
OpenAlexW4379053452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.