ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Automated detection of progressive speech changes in early Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Speech-based digital biomarkers for early etiological stratification of Alzheimer's disease and frontotemporal degeneration: a biomarker-confirmed prospective study.The journal of prevention of Alzheimer's disease · 2026Article
- Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias.Seminars in neurology · 2026Review
- The Utility of Speech and Language Analytics for Screening Alzheimer's Disease.Neuro-degenerative diseases · 2026Review
- Article
- Objective speech measures capture depressive symptoms and associated cognitive difficulties.Translational psychiatry · 2025Article
- Automated Speech Markers of Alzheimer Dementia: Test of Cross-Linguistic Generalizability.Journal of medical Internet research · 2025Article
- A Systematic Review of Natural Language Processing Techniques for Early Detection of Cognitive Impairment.Mayo Clinic proceedings. Digital health · 2025Review
- Storyteller in ADNI4: Application of an early Alzheimer's disease screening tool using brief, remote, and speech-based testing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Responsible development of clinical speech AI: Bridging the gap between clinical research and technology.NPJ digital medicine · 2024Review
- Speech patterns during memory recall relates to early tau burden across adulthood.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Observational
- Linguistic changes in neurodegenerative diseases relate to clinical symptoms.Frontiers in neurology · 2024Article
- Automated detection of progressive speech changes in early Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Natural language processing in Alzheimer's disease research: Systematic review of methods, data, and efficacy.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Speech and language changes occur in Alzheimer's disease (AD), but few studies have characterized their longitudinal course. We analyzed open-ended speech samples from a prodromal-to-mild AD cohort to develop a novel composite score to characterize progressive speech changes. Participant speech from the Clinical Dementia Rating (CDR) interview was analyzed to compute metrics reflecting speech and language characteristics. We determined the aspects of speech and language that exhibited significant longitudinal change over 18 months. Nine acoustic and linguistic measures were combined to create a novel composite score. The speech composite exhibited significant correlations with primary and secondary clinical endpoints and a similar effect size for detecting longitudinal change. Our results demonstrate the feasibility of using automated speech processing to characterize longitudinal change in early AD. Speech-based composite scores could be used to monitor change and detect response to treatment in future research. HIGHLIGHTS: Longitudinal speech samples were analyzed to characterize speech changes in early AD.Acoustic and linguistic measures showed significant change over 18 months.A novel speech composite score was computed to characterize longitudinal change.The speech composite correlated with primary and secondary trial endpoints.Automated speech analysis could facilitate remote, high frequency monitoring in AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.