ArticleFrontiers in public health2023
Adverse short-term effects of ozone on cardiovascular mortalities modified by season and temperature: a time-series study.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Key factors in epidemiological exposure and insights for environmental management: Evidence from meta-analysis.Environmental pollution (Barking, Essex : 1987) · 2024Pooled it
- Mortality risk effects of ozone and meteorological factors: a 10-year time-series study.Frontiers in public health · 2026Article
- Integrated risks from air pollution and climate extremes: synergistic effects of ozone, heat, and humidity on cardiovascular mortality.BMC medicine · 2025Article
- Short-term effects of extreme air pollutant concentrations on coronary heart disease hospitalization in Henan province: a time-stratified case-crossover study.Frontiers in cardiovascular medicine · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Interaction effects of high temperature and ozone on cardiovascular disease mortality in Chengdu, 2014-2023.Frontiers in public health · 2025Article
- Association of Ozone and Temperature with Ischemic Heart Disease Mortality Risk: Mediation and Interaction Analyses.Environmental science & technology · 2024Article
- A bibliometric analysis of research on the health impacts of ozone air pollution.Environmental science and pollution research international · 2024Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Ambient ozone pollution becomes critical in China. Conclusions on the short-term effects of ozone on cardiovascular mortality have been controversial and limited on cause-specific cardiovascular mortalities and their interactions with season and temperature. This research aimed to investigate the short-term effects of ozone and the modifications of season and temperature on cardiovascular mortality. Methods: Cardiovascular death records, air pollutants, and meteorological factors in Shenzhen from 2013 to 2019 were analyzed. Daily 1-h maximum of ozone and daily maximum 8-h moving average of ozone were studied. Generalized additive models (GAMs) were applied to evaluate their associations with cardiovascular mortalities in sex and age groups. Effect modifications were assessed by stratifying season and temperature. Results: Distributed lag impacts of ozone on total cardiovascular deaths and cumulative effects on mortality due to ischemic heart disease (IHD) were most significant. Population under 65 years old was most susceptible. Majority of significant effects were found in warm season, at high temperature, and at extreme heat. Ozone-associated risks in total deaths caused by hypertensive diseases reduced in warm season, while risks in IHD in males increased at high temperature. Extreme heat enhanced ozone effects on deaths caused by CVDs and IHD in the population under 65 years old. Discussion: The revealed cardiovascular impacts of ozone below current national standard of air quality suggested improved standards and interventions in China. Higher temperature, particularly extreme heat, rather than warm season, could significantly enhance the adverse effects of ozone on cardiovascular mortality in population under 65 years old.
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