ArticleThe Lancet regional health. Western Pacific2023
Changes in neurological outcomes of out-of-hospital cardiac arrest during the COVID-19 pandemic in Japan: a population-based nationwide observational study.
Article in The Lancet regional health. Western Pacific, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Practical adaptability of a pre-hospital prognostic prediction model for patients following out-of-hospital cardiac arrest during the COVID-19 pandemic.BMJ health & care informatics · 2026Article
- Factors influencing the prognosis of out-of-hospital cardiac arrest during the coronavirus disease 2019 pandemic: an analysis of the Utstein Registry in Aichi, Japan.BMC emergency medicine · 2026Observational
- Out-of-hospital cardiac arrest outcomes following EMS resuscitation protocol revision during the COVID-19 pandemic: a population-based study.Resuscitation plus · 2025Article
- A retrospective cohort study on impact of Covid-19 outbreak on out-of-hospital cardiac arrest (OHCA) in Telangana, India: mortality trends, contributing factors, and research imperatives.BMC public health · 2025Article
- Out-of-hospital cardiac arrest survival in Black & Hispanic communities since the COVID-19 pandemic.Resuscitation · 2025Article
- Impact of the COVID-19 Pandemic on Out-of-Hospital Cardiac Arrests Occurring in the Workplace.Cureus · 2025Article
- Effects of Post-Hospital Arrival Factors on Out-of-Hospital Cardiac Arrest Outcomes During the COVID-19 Pandemic.Critical care explorations · 2024Article
- The Incidence and Outcomes of Out-of-Hospital Cardiac Arrest During the COVID-19 Pandemic in South Korea: Multicenter Registry Study.JMIR public health and surveillance · 2024Observational
- Association between defibrillation-to-adrenaline interval and short-term outcomes in patients with out-of-hospital cardiac arrest and an initial shockable rhythm.Resuscitation plus · 2024Article
- Out-of-Hospital Cardiac Arrest Following the COVID-19 Pandemic.JAMA network open · 2024Observational
- Difficult-to-transport cases and neurological outcomes of out-of-hospital cardiac arrest: A population-based nationwide study in Japan.Acute medicine & surgeryArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is growing interest in the indirect negative effects of coronavirus disease 2019 (COVID-19) on mortality. We aimed to assess its indirect effect on out-of-hospital cardiac arrest (OHCA) outcomes. Methods: We analysed a prospective nationwide registry of 506,935 patients with OHCA between 2017 and 2020. The primary outcome was favourable neurological outcome (Cerebral Performance Category 1 or 2) at 30 days. The secondary outcomes were public access defibrillation (PAD) and bystander-initiated chest compression. We performed an interrupted time series (ITS) analysis to assess changes in the trends of these outcomes around the declaration of a state of emergency (April 7 - May 25, 2020). We also performed a subgroup analysis stratified by infection spread status. Findings: We identified 21,868 patients with OHCA witnessed by a bystander who had an initial shockable heart rhythm. ITS analysis showed a drastic decline in PAD use (relative risk [RR], 0.60; 95% confidence interval [CI], 0.49-0.72; p < 0.0001) and a reduction in favourable neurological outcomes (RR, 0.79; 95% CI, 0.68-0.91; p = 0.0032) all over Japan after the state of emergency was declared when compared with the equivalent time period in previous years. The decline in favourable neurological outcomes was more pronounced in areas with COVID-19 spread than in areas without spread (RR, 0.70; 95% CI, 0.58-0.86 vs. RR, 0.87; 95% CI, 0.72-1.03; p for effect modification = 0.019). Interpretation: COVID-19 is associated with worse neurological outcomes and less PAD use in patients with OHCA. Funding: None.
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