Evidence map›Paper›PMID 37360389›Full record

ArticleRSC medicinal chemistry2023

Detection of intact vancomycin-arginine as the active antibacterial conjugate in

Sabrina H Werby, Jasna Brčić, Madeline B Chosy, Jiuzhi Sun, Jacob T Rendell, Lewis F Neville, Paul A Wender, Lynette Cegelski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sabrina H WerbyDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.
Jasna BrčićDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.
Madeline B ChosyDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.
Jiuzhi SunDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.
Jacob T RendellSuperTrans Medical Ltd. Ness Ziona Israel.
Lewis F NevilleSuperTrans Medical Ltd. Ness Ziona Israel.
Paul A WenderDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.
Lynette CegelskiDepartment of Chemistry, Stanford University Stanford CA 94305 USA wenderp@stanford.edu cegelski@stanford.edu.ORCID https://orcid.org/0000-0002-0978-1814
Stanford University · US

Funding

SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENTR01CA031845 · NCI · STANFORD UNIVERSITY · PI PAUL Anthony WENDER · 1985 to 2026
$6.9M
Synthetic Studies Related to Cancer Research/TreatmentR37CA031845 · NCI · STANFORD UNIVERSITY · PI WENDER, PAUL ANTHONY · 2006 to 2015
$4.5M
Bacterial Cell Wall Composition and the Influence of AntibioticsR01GM117278 · NIGMS · STANFORD UNIVERSITY · PI CEGELSKI, LYNETTE S · 2016 to 2023
$2.6M
NCI NIH HHS R01 CA031845NCI NIH HHS R37 CA031845NIGMS NIH HHS R01 GM117278
6 · The paper itself

Abstract

The introduction of new and improved antibacterial agents based on facile synthetic modifications of existing antibiotics represents a promising strategy to deliver urgently needed antibacterial candidates to treat multi-drug resistant bacterial infections. Using this strategy, vancomycin was transformed into a highly active agent against antibiotic-resistant Gram-negative organisms

Identifiers

PMID37360389
PMCPMC10285746
OpenAlexW4377247950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.