ArticleFrontiers in neurology2023
Inflammation in stroke: initial CRP levels can predict poor outcomes in endovascularly treated stroke patients.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Association of Cardiovascular Risk Burden with Cardiorespiratory Fitness and Functional Performance in Patients with Post-Stroke Spasticity: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Association between stress hyperglycemia ratio and early neurological deterioration after acute ischemic stroke: a retrospective cohort study.BMC neurology · 2026Article
- Comparison of short-and long-term prognostic differences and validation of clinical prediction models between two types of mechanical thrombectomy in patients with acute ischemic stroke aged 75 years and above.Frontiers in medicine · 2026Article
- Association of CRP levels and clinical and radiological outcomes in patients with large-vessel occlusion stroke: A MR CLEAN Registry study.European stroke journal · 2026Article
- FIB-4 Index, Systemic Inflammation, and Troponin Trajectory After Endovascular Thrombectomy in Older Patients with Large-Vessel Occlusion Stroke.Clinical interventions in aging · 2026Article
- Monomeric C-reactive Protein Exacerbates Neuronal Injury and Enhances Microglial Activation after Global Cerebral Ischemia in Mice.Molecular neurobiology · 2025Article
- The Association Between FT4/FT3 Ratio and Prognosis in Ischemic Stroke: A Retrospective Cohort Study.Brain and behavior · 2025Article
- Serum Biomarkers in Acute Ischemic Stroke: Clinical Applications and Emerging Insights.Journal of clinical medicine · 2025Review
- Tracing Inflammation in Ischemic Stroke: Biomarkers and Clinical Insight.International journal of molecular sciences · 2025Review
- Association of CRP levels and clinical and radiological outcomes in patients with large-vessel occlusion stroke: A MR CLEAN Registry study.European stroke journal · 2025Article
- Age-Specific Differences in Inflammatory Biomarkers and Their Impact on Futile Recanalization After Mechanical Thrombectomy: An Inverse Probability Weighting Analysis.European journal of neurology · 2025Observational
- Fluid excess on intensive care unit after mechanical thrombectomy after acute ischemic stroke is associated with unfavorable neurological and functional outcomes: An observational cohort study.European stroke journal · 2025Observational
- Drug screening for ischemic stroke using larvae and adult zebrafish model: a review.Laboratory animal research · 2025Review
- Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy.Frontiers in aging neuroscience · 2025Article
- Effect of inflammation on neurovascular coupling, microperfusion, and clinical outcomes in ischemic stroke patients: a case series report.Frontiers in medicine · 2025Article
- Effectiveness of remote ischaemic conditioning is not affected by hyper-inflammation in a rat model of stroke.Scientific reports · 2024Article
- Chronic Kidney Disease Increases Mortality and Reduces the Chance of a Favorable Outcome in Stroke Patients Treated with Mechanical Thrombectomy-Single-Center Study.Journal of clinical medicine · 2024Article
- Efficacy and safety of mechanical thrombectomy in the posterior cerebral circulation-a single center study.Scientific reports · 2024Article
- Article
- Predictors of futile recanalization in completely recanalized middle cerebral artery occlusions: multicenter study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Inflammation has been linked to poor prognoses in cardio- and cerebrovascular conditions. As it is known to increase after ischemia, C-reactive protein (CRP) may serve as a surrogate for systemic inflammation and thus be a hallmark of increased tissue vulnerability. The question arises whether CRP in the acute phase of ischemic stroke, prior to mechanical thrombectomy (MT), might help predict outcomes. Materials and methods: A single-center collective of patients with large-vessel occlusion, who were treated via MT, was analyzed in this observational case-control study. Univariate and multivariate models were designed to test the prognostic value of inflammatory markers (CRP and leukocytosis) in predicting clinical outcomes (modified Rankin score >2) and all-cause mortality 90 days after MT. Results: A total of 676 ischemic stroke patients treated with MT were included. Of these, 313 (46.3%) showed elevated CRP levels (≥5 mg/l) on admission. Poor clinical outcome and mortality at 90 days occurred in 113 (16.7%) and 335 (49.6%) patients and significantly more frequently when initial CRP levels were elevated [213 (64.5%) vs. 122 (42.1%), Conclusion: Poor outcome and death occur significantly more often in stroke patients with elevated CRP levels before MT. Our findings suggest that stroke patients with atrial fibrillation and elevated inflammatory markers are of particular risk for poor outcomes.
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