ArticleAdvances in laboratory medicine2023
Handling of lipemic samples in the clinical laboratory.
Article in Advances in laboratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Compartment-specific skeletal involvement in systemic sclerosis characterized by peripheral QCT and serum osteoimmune mediators: a case-control study.Calcified tissue international · 2026Article
- Severe Hypertriglyceridemia With Lipemia-Induced Analytical Interference: Diagnostic Challenges in a Chylomicronemia Phenotype.JACC. Case reports · 2026Article
- Lipid Interference Flagging and Haemoglobin Correction in Lipemic Samples With a Hematology Analyzer.Journal of clinical laboratory analysis · 2026Article
- Evaluation of the difference between mean corpuscular haemoglobin concentration and mean cellular haemoglobin concentration in canine complete blood count assessed with an automated haematology analyser.The Journal of small animal practice · 2026Article
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- Rapid Serological Detection of Anti-GM-CSF Autoantibodies in Autoimmune Pulmonary Alveolar Proteinosis Using a Novel Immunochromatographic Test.Respirology (Carlton, Vic.) · 2026Article
- Clinical utility of optical scatter-derived red blood cell parameters for the rapid identification and correction of lipemic interference.Frontiers in medicine · 2026Article
- Pitfalls of onco-metabolomics: impact of sample integrity on metabolomic investigations in more than 4500 human serum samples from ten different cohorts.Frontiers in molecular biosciences · 2026Article
- Lipemia and its associations with liver disease and dyslipidemia: a cross-sectional study.Lipids in health and disease · 2025Article
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- Analytical and Quality Control Validation of a Novel Symmetric Dimethylarginine Assay in Dogs and Cats.Veterinary clinical pathology · 2025Article
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- How to handle lipemic CBC samples on Sysmex hematology analyzers?Advances in laboratory medicine · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferences in the clinical laboratory may lead physicians misinterpret results for some biological analytes. The most common analytical interferences in the clinical laboratory include hemolysis, icterus and lipemia. Lipemia is defined as turbidity in a sample caused by the accumulation of lipoproteins, mainly very-low density lipoproteins (VLDL) and chylomicrons. Several methods are available for the detection of lipemic samples, including the lipemic index, or triglyceride quantification in serum or plasma samples, or mean corpuscular hemoglobin (MCHC) concentration in blood samples. According to the European Directive 98/79/CE, it is the responsibility of clinical laboratories to monitor the presence of interfering substances that may affect the measurement of an analyte. There is an urgent need to standardize interference studies and the way interferences are reported by manufacturers. Several methods are currently available to remove interference from lipemia and enable accurate measurement of biological quantities. The clinical laboratory should establish a protocol for the handling of lipemic samples according to the biological quantity to be tested.
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