ArticleAdvances in laboratory medicine2023
Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQC
Article in Advances in laboratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06136208 (Pharmacokinetic Aspects of 25-mg Estradiol Pellet in Climacteric Women Comprehensive Longitudinal Assessment of Release With Estradiol Pellet Analysis), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetic Aspects of 25-mg Estradiol Pellet in Climacteric Women Comprehensive Longitudinal Assessment of Release With Estradiol Pellet Analysis (CLARA Study)
Who cites it
15 citing papers in PubMed.
- Facing the diagnosis of hyperandrogenic polycystic ovary syndrome by a novel combination of circulating biomarkers.Scientific reports · 2026Article
- Androgen profiling in adolescent girls with polycystic ovary syndrome.Frontiers in endocrinology · 2026Article
- Ovarian Escape in Hormone Receptor-Positive Breast Cancer: Mechanisms, Risk Factors, Clinical Consequences, and Management Strategies.Breast cancer (Dove Medical Press) · 2026Review
- Longitudinal Analysis of Estrogen Receptor Gene Methylation, Estradiol, and Depressive Symptoms During the Perinatal Period.Molecular neurobiology · 2025Article
- Serum norethisterone (NET) levels in NET-enanthate (NET-EN) injectable contraception users substantially interfere with testosterone immunoassay measurements and confound interpretation of biological outcomes.Contraception and reproductive medicine · 2025Article
- Peripheral precocious puberty in girls with McCune-Albright syndrome: a case series.Archives of endocrinology and metabolism · 2025Article
- Estrogens and Progestogens in Environmental Waters: Analytical Chemistry and Biosensing Perspectives on Methods, Challenges, and Trends.Analytical chemistry · 2025Review
- Guidelines for sex-specific considerations to improve rigor in renal research and how we got there.American journal of physiology. Renal physiology · 2025Review
- Influence of state-of-the-art laboratory techniques on the phenotyping of women with polycystic ovary syndrome in the clinical setting.Journal of endocrinological investigation · 2025Article
- Current Role and Potential of Triple Quadrupole Mass Spectrometry in Biomedical Research and Clinical Applications.Molecules (Basel, Switzerland) · 2024Review
- History of the Development of Knowledge about the Neuroendocrine Control of Ovulation-Recent Knowledge on the Molecular Background.International journal of molecular sciences · 2024Review
- Dihydrotestosterone induces arterial stiffening in female mice.Biology of sex differences · 2024Article
- Improving LC-MS/MS measurements of steroids with differential mobility spectrometry.Journal of mass spectrometry and advances in the clinical lab · 2023Article
- Longitudinal Course of Sex Steroids From Pregnancy to Postpartum.Endocrinology · 2023Review
- Recommendations for the measurement of sexual steroids. A step forward in the silent revolution of mass spectrometry.Advances in laboratory medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.