Evidence map›Paper›PMID 37359514›Full record

ArticleFrontiers in immunology2023

Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection.

Teresia W Maina, Elizabeth A Grego, Scott Broderick, Randy E Sacco, Balaji Narasimhan, Jodi L McGill

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Informatics-Based Design of Virtual Libraries of Polymer Nano-Composites.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Teresia W MainaDepartment of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, United States.
Elizabeth A GregoDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, United States.
Scott BroderickDepartment of Materials Design and Innovation, University at Buffalo, Buffalo, NY, United States.
Randy E SaccoRuminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture (USDA), Ames, IA, United States.
Balaji NarasimhanDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, United States.
Jodi L McGillDepartment of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, United States.
Iowa State University · USUniversity at Buffalo, State University of New York · US

Funding

Development of a mucosal, polyanhydride-based nanoparticle vaccine for use against RSV infection in the neonateR01HD095880 · NICHD · IOWA STATE UNIVERSITY · PI MCGILL, JODI, SACCO, RANDY E · 2019 to 2022
$2.1M
NICHD NIH HHS R01 HD095880
6 · The paper itself

Abstract

Human respiratory syncytial virus (HRSV) is a leading cause of death in young children and there are no FDA approved vaccines. Bovine RSV (BRSV) is antigenically similar to HRSV, and the neonatal calf model is useful for evaluation of HRSV vaccines. Here, we determined the efficacy of a polyanhydride-based nanovaccine encapsulating the BRSV post-fusion F and G glycoproteins and CpG, delivered prime-boost

Indexed as

PolyanhydridesRespiratory Syncytial Virus, BovineRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAnimalsCattleChildChild, PreschoolGTP-Binding ProteinsHumansLungVaccinationGTP-Binding ProteinsPolyanhydridesbovine respiratory diseasebovine respiratory syncytial virushuman respiratory syncytial virusimmunologynanoparticlesnanovaccinesneonatal calf model

Identifiers

PMID37359514
PMCPMC10289034
OpenAlexW4380090237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.