Evidence map›Paper›PMID 37358954›Full record

ArticleFrontiers in aging neuroscience2023

Distinct and shared neuropsychiatric phenotypes in FTLD-tauopathies.

Rachel Keszycki, Allegra Kawles, Grace Minogue, Antonia Zouridakis, Alyssa Macomber, Nathan Gill, My Vu, Hui Zhang, Christina Coventry, Emily Rogalski and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Rachel KeszyckiMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Allegra KawlesMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Grace MinogueMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Antonia ZouridakisMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Alyssa MacomberMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Nathan GillMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
My VuMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Hui ZhangMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Christina CoventryMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Emily RogalskiMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
M-Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Tamar GefenMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Northwestern University · US

Funding

Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANGIZ GEULA · 2021 to 2026
$26.3M
ASYMMETRIC NEURODEGENERATION AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIAR01AG077444 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAREK-MARSEL M MESULAM, EMILY J ROGALSKI · 2022 to 2026
$10.4M
TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical PhenotypeR01NS085770 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ · 2014 to 2024
$5.0M
Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard)R01AG062566 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEFEN, TAMAR D · 2020 to 2024
$2.1M
Vulnerability Profiles of Comorbid Alzheimer and TDP-43 Proteinopathies in Amnestic DementiaR56AG075600 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEFEN, TAMAR D · 2023 to 2023
$603k
Pathologic Substrates of Neuropsychiatric Symptoms in Aphasic DementiaF31AG076318 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KESZYCKI, RACHEL M · 2022 to 2024
$122k
NIA NIH HHS F31 AG076318NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG062566NIA NIH HHS R01 AG077444NIA NIH HHS R56 AG075600NINDS NIH HHS R01 NS085770NINDS NIH HHS T32 NS047987
6 · The paper itself

Abstract

Frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau) commonly causes dementia syndromes that include primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD). Cognitive decline in PPA and bvFTD is often accompanied by debilitating neuropsychiatric symptoms. In 44 participants with PPA or bvFTD due to autopsy-confirmed FTLD-tau, we characterized neuropsychiatric symptoms at early and late disease stages and determined whether the presence of certain symptoms predicted a specific underlying FTLD-tauopathy. Participants completed annual research visits at the Northwestern University Alzheimer's Disease Research Center. All participants had an initial Global Clinical Dementia Rating (CDR) Scale score ≤ 2, and neuropsychiatric symptoms were evaluated

Indexed as

behavioral variant frontotemporal dementiacorticobasal degenerationfrontotemporal lobar degenerationneuropsychiatric symptomspick diseaseprimary progressive aphasiaprogressive supranuclear palsy

Identifiers

PMID37358954
PMCPMC10289868
OpenAlexW4380084599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.