Evidence map›Paper›PMID 37358929›Full record

ArticleNano letters2023

Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution.

Ian Houlihan, Benjamin Kang, Smita De, Vijay Krishna

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ian HoulihanBiomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland Ohio 44195, United States.ORCID 0000-0002-4142-0736
Benjamin KangBiomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland Ohio 44195, United States.
Smita DeUrology, Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland Ohio 44195, United States.
Vijay KrishnaBiomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland Ohio 44195, United States.ORCID 0000-0003-3400-7764
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

KUH-TN Training CoreTL1DK132770 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Evi X. Stavrou · 2021 to 2026
$2.5M
NIDDK NIH HHS TL1 DK132770
6 · The paper itself

Abstract

Near-infrared activated nanomaterials have been reported for biomedical applications ranging from photothermal tumor destruction to biofilm eradication and energy-gated drug delivery. However, the focus so far has been on soft tissues, and little is known about energy delivery to hard tissues, which have thousand-fold higher mechanical strength. We present photonic lithotripsy with carbon and gold nanomaterials for fragmenting human kidney stones. The efficacy of stone comminution is dependent on the size and photonic properties of the nanomaterials. Surface restructuring and decomposition of calcium oxalate to calcium carbonate support the contribution of photothermal energy to stone failure. Photonic lithotripsy has several advantages over current laser lithotripsy, including low operating power, noncontact laser operation (distances of at least 10 mm), and ability to break all common stones. Our observations can inspire the development of rapid, minimally invasive techniques for kidney stone treatment and extrapolate to other hard tissues such as enamel and bone.

Indexed as

Kidney CalculiLithotripsyLithotripsy, LaserHumansLasersLightcalcium oxalatecarbon nanomaterialsgold nanomaterialslithotripsylow intensity lasernoncontact laser

Identifiers

PMID37358929
PMCPMC10348310
OpenAlexW4382055397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.