Evidence map›Paper›PMID 37358806›Full record

ArticlePsychopharmacology2023

Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition.

Alev Ecevitoglu, Gayle A Edelstein, Rose E Presby, Renee A Rotolo, Jen-Hau Yang, Taina Quiles, Kevin Okifo, Ryan T Conrad, Ashley Kovach, Merce Correa and 1 more

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Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Alev EcevitogluDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Gayle A EdelsteinDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Rose E PresbyDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Renee A RotoloDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Jen-Hau YangDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Taina QuilesDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Kevin OkifoDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Ryan T ConradDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Ashley KovachDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Merce CorreaDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
John D SalamoneDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA. john.salamone@uconn.edu.
University of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleCariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial agonist. In addition to treating positive symptoms of schizophrenia, cariprazine may have utility for treating negative symptoms. Rodent studies have focused on the effects of cariprazine on cognitive functions and behaviors thought to be related to anhedonia. Avolition, which is characterized by reduced initiation and persistence of goal-directed behavior, is another important negative symptom.

objectivesEffort-related choice tasks have been used as animal models of avolition. In these studies, cariprazine was assessed for its effects on effort-based choice in both rats and mice. Previous work has shown that D2 antagonists such as haloperidol and eticlopride produce a low-effort bias in rodents tested on effort-based choice tasks.

resultsLow doses of cariprazine produced a low-effort bias in rats tested on the fixed ratio 5/chow feeding choice task, decreasing lever pressing for high carbohydrate pellets but increasing chow intake. Cariprazine did not alter preference or intake of these foods in free-feeding tests. The effort-related effects of cariprazine were reversed by co-administration of the adenosine A

conclusionsThese results demonstrate that with these rodent models of avolition, cariprazine appears to act like a D2-family antagonist even at very low doses. Furthermore, the pharmacological regulation of avolition may differ from that of other negative symptoms.

Indexed as

Antipsychotic AgentsAnimalsChoice BehaviorDopamineDopamine AgonistsMicePiperazinesRatsRats, Sprague-DawleyAntipsychotic AgentscariprazineDopamineDopamine AgonistsPiperazinesEffort-related decision makingMotivationMouse touchscreenNegative symptomsOperantSchizophrenia

Identifiers

PMID37358806
OpenAlexW4382010793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.