Evidence map›Paper›PMID 37358734›Full record

ReviewHuman cell2023

Advances in combined application of dental stem cells and small-molecule drugs in regenerative medicine.

Zejun Zheng, Shuai Tang, Tong Yang, Xiaolan Wang, Gang Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zejun ZhengSchool of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China.
Shuai TangSchool of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China.
Tong YangSchool of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China.
Xiaolan WangSchool of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China.
Gang DingSchool of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China. dinggang@wfmc.edu.cn.ORCID http://orcid.org/0000-0003-4597-1639

Funding

National Natural Science Foundation of China 81570945Natural Science Foundation of Shandong Province ZR2021MH051Postgraduate Education Quality Improvement Plan of Shandong Province SDYAL21150
6 · The paper itself

Abstract

Teeth are a kind of masticatory organs of special histological origin, unique to vertebrates, playing an important role in chewing, esthetics, and auxiliary pronunciation. In the past decades, with the development of tissue engineering and regenerative medicine, the studies of mesenchymal stem cells (MSCs) gradually attracted the interest of researchers. Accordingly, several types of MSCs have been successively isolated in teeth or teeth-related tissues, including dental pulp stem cells, periodontal ligament stem cells, stem cells from human exfoliated deciduous teeth, dental follicle stem cells, stem cells from apical papilla and gingival mesenchymal stem cells. These dental stem cells (DSCs) are easily accessible, possess excellent stem cell characteristics, such as high proliferation rates and profound immunomodulatory properties. Small-molecule drugs are widely used and show great advantages in clinical practice. As research progressed, small-molecule drugs are found to have various complex effects on the characteristics of DSCs, especially the enhancement of biological characteristics of DSCs, which has gradually become a hot issue in the field of DSCs research. This review summarizes the background, current status, existing problems, future research directions, and prospects of the combination of DSCs with three common small-molecule drugs: aspirin, metformin, and berberine.

Indexed as

Mesenchymal Stem CellsToothAnimalsDental PulpHumansPeriodontal LigamentRegenerative MedicineTissue EngineeringDental stem cellMesenchymal stem cellRegenerative medicineSmall-molecule drugsTooth

Identifiers

PMID37358734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.