ArticleEuropean journal of nutrition2023
Soybean glycinin and β-conglycinin damage the intestinal barrier by triggering oxidative stress and inflammatory response in weaned piglets.
Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative Effects of Processed Soybean Protein Sources on Growth, Serum Immune and Endocrine Profiles, and Colonic Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- Targeted Reduction of Specific Antinutritional and Allergen-Associated Proteins to Advance Soybean Seed Quality.International journal of molecular sciences · 2026Article
- Potassium Diformate Attenuates Inflammation and Enhances Intestinal Barrier Function Associated With Gut Microbiota Modulation in Nursery Piglets.Food science & nutrition · 2026Article
- Drying Temperature Dictates Ileal Amino Acid Digestibility of Enzyme-Treated Soybean Meal in 25 kg Pigs.Animals : an open access journal from MDPI · 2025Article
- Comparative effects of replacing soybean meal in feeds with processed soybean meal on intestinal health and growth of nursery pigs when fed pharmacological level of zinc.Animal bioscience · 2025Article
- Effect of Fermented Feed on Growth Performance and Gut Health of Broilers: A Review.Animals : an open access journal from MDPI · 2025Review
- SoybeanAnimals : an open access journal from MDPI · 2025Article
- Brown Algae Polysaccharides Alleviate Diquat-Induced Oxidative Stress in Piglets and IPEC-J2 Cells via Nrf2/ARE Signaling Pathway.Animals : an open access journal from MDPI · 2025Article
- Article
- The role of lycopene in alleviating soybean meal-induced intestinal injury in an early-weaned piglet model.Frontiers in veterinary science · 2025Article
- The study of the antinutritional threshold of glycinin in piglets: impact on growth performance, nutrient digestion, allergic reactions, intestinal permeability and morphology.Frontiers in veterinary science · 2025Article
- The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications.Clinical and experimental medicine · 2024Review
- Dietary Protease Supplementation Improved Growth Performance and Nutrients Digestion via Modulating Intestine Barrier, Immunological Response, and Microbiota Composition in Weaned Piglets.Antioxidants (Basel, Switzerland) · 2024Article
- Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Tryptophan metabolism and piglet diarrhea: Where we stand and the challenges ahead.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Impact of ovalbumin allergy on oral and gut microbiome dynamics in 6-week-old BALB/c mice.Frontiers in microbiology · 2024Article
- Integrative RNA, miRNA, and 16S rRNA sequencing reveals immune-related regulation network for glycinin-induced enteritis in hybrid yellow catfish,Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeSoybean glycinin (11S) and β-conglycinin (7S) are major antigenic proteins in soybean and can induce a variety of allergic reactions in the young animals. This study aimed to investigate the effect of 7S and 11S allergens on the intestine of piglets.
methodsThirty healthy 21-day-old weaned "Duroc × Long White × Yorkshire" piglets were randomly divided into three groups fed with the basic diet, the 7S supplemented basic diet, or the 11S supplemented basic diet for 1 week. Allergy markers, intestinal permeability, oxidative stress, and inflammatory reactions were detected, and we observed different sections of intestinal tissue. The expressions of genes and proteins related to NOD-like receptor thermal protein domain associated protein 3 (NLRP-3) signaling pathway were detected by IHC, RT-qPCR, and WB.
resultsSevere diarrhea and decreased growth rate were observed in the 7S and 11S groups. Typical allergy markers include IgE production and significant elevations of histamine and 5-hydroxytryptamine (5-HT). More aggressive intestinal inflammation and barrier dysfunction were observed in the experimental weaned piglets. In addition, 7S and 11S supplementation increased the levels of 8-hydroxy-2 deoxyguanosine (8-OHdG) and nitrotyrosine, triggering oxidative stress. Furthermore, higher expression levels of NLRP-3 inflammasome ASC, caspase-1, IL-1β, and IL-18 were observed in the duodenum, jejunum, and ileum.
conclusionWe confirmed that 7S and 11S damaged the intestinal barrier of weaned piglets and may be associated with the onset of oxidative stress and inflammatory response. However, the molecular mechanism underlying these reactions deserves further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.