Evidence map›Paper›PMID 37358570›Full record

ArticleExperimental brain research2023

Oral probiotic therapy improves motor function in a rodent model of sensorimotor stroke.

E Daniele, Y Nazer, I Kortebi, D Lozano Casasbuenas, Y Fan, M Trinh, T A Tompkins, M Faiz

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

E DanieleDepartment of Surgery, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2189-4678
Y NazerDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
I KortebiDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
D Lozano CasasbuenasDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Y FanDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
M TrinhDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
T A TompkinsLallemand BioIngredients, Montreal, QC, Canada.
M FaizDepartment of Surgery, University of Toronto, Toronto, ON, Canada. maryam.faiz@utoronto.ca.ORCID http://orcid.org/0000-0003-0671-3557
University of Toronto · CALallemand (Canada) · CA

Funding

Mitacs IT16930
6 · The paper itself

Abstract

Ischemic stroke is a debilitating neurological disease with few effective therapeutics. Previous work has shown that oral probiotic treatment prior to stroke can attenuate cerebral infarction and neuroinflammation, highlighting the gut-microbiota-brain axis as a novel therapeutic target. Whether a more clinically relevant, post-stroke, administration of probiotics can improve stroke outcomes is unknown. In this study, we examined the effect of post-stroke oral probiotic therapy on motor behavior in the pre-clinical mouse endothelin-1 (ET-1) model of sensorimotor stroke. We found that post-stroke oral probiotic therapy with Cerebiome

Indexed as

ProbioticsStrokeAnimalsMiceRodentiaGut–brain axisMicrogliaProbioticsSensorimotor stroke

Identifiers

PMID37358570
OpenAlexW4382010714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.