Evidence map›Paper›PMID 37358306›Full record

ArticleAmerican journal of human biology : the official journal of the Human Biology Council2023

Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.

Beatrice Caffé, Aaron Blackwell, Bethaney D Fehrenkamp, Janet E Williams, Ryan M Pace, Kimberly A Lackey, Lorena Ruiz, Juan M Rodríguez, Mark A McGuire, James A Foster and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human biology : the official journal of the Human Biology Council, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Beatrice CafféDepartment of Anthropology, Washington State University, Pullman, Washington, USA.
Aaron BlackwellDepartment of Anthropology, Washington State University, Pullman, Washington, USA.
Bethaney D FehrenkampMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.
Janet E WilliamsDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.
Ryan M PaceMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.
Kimberly A LackeyMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.
Lorena RuizDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Spain.
Juan M RodríguezDepartment of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
Mark A McGuireDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.
James A FosterDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Daniel W SellenDepartment of Anthropology, University of Toronto, Toronto, Ontario, Canada.
Elizabeth W Kamau-MbuthiaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Egidioh W KamundiaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Samwel MbuguaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Sophie E MooreDepartment of Women and Children's Health, King's College London, London, UK.
Andrew M PrenticeMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Linda J KvistFaculty of Medicine, Lund University, Lund, Sweden.
Gloria E OtooDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Rossina G ParejaNutrition Research Institute, Lima, Peru.
Lars BodeLarsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, California, USA.
Dubale GebeyehuDepartment of Anthropology, Hawassa University, Hawassa, Ethiopia.
Debela K GindolaDepartment of Anthropology, Hawassa University, Hawassa, Ethiopia.
Sarah BoothmanSchool of Biological Sciences, Washington State University, Pullman, Washington, USA.
Katherine FloresDepartment of Anthropology, Washington State University, Pullman, Washington, USA.
Michelle K McGuireMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.
Courtney L MeehanDepartment of Anthropology, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-2034-652X

Funding

Mammary and milk microbiomes and metabolomes - Understanding early variation and impacts on risk for mammary inflammation and mastitisR01HD092297 · NICHD · UNIVERSITY OF IDAHO · PI MCGUIRE, MICHELLE KAY · 2018 to 2022
$2.4M
Medical Research Council MC_PC_21037Medical Research Council MC_UU_00026/3NICHD NIH HHS R01 HD092297NIH HHS
6 · The paper itself

Abstract

objectivesBreastfeeding is an energetically costly and intense form of human parental investment, providing sole-source nutrition in early infancy and bioactive components, including immune factors. Given the energetic cost of lactation, milk factors may be subject to tradeoffs, and variation in concentrations have been explored utilizing the Trivers-Willard hypothesis. As human milk immune factors are critical to developing immune system and protect infants against pathogens, we tested whether concentrations of milk immune factors (IgA, IgM, IgG, EGF, TGFβ2, and IL-10) vary in response to infant sex and maternal condition (proxied by maternal diet diversity [DD] and body mass index [BMI]) as posited in the Trivers-Willard hypothesis and consider the application of the hypothesis to milk composition.

methodsWe analyzed concentrations of immune factors in 358 milk samples collected from women residing in 10 international sites using linear mixed-effects models to test for an interaction between maternal condition, including population as a random effect and infant age and maternal age as fixed effects.

resultsIgG concentrations were significantly lower in milk produced by women consuming diets with low diversity with male infants than those with female infants. No other significant associations were identified.

conclusionsIgG concentrations were related to infant sex and maternal diet diversity, providing minimal support for the hypothesis. Given the lack of associations across other select immune factors, results suggest that the Trivers-Willard hypothesis may not be broadly applied to human milk immune factors as a measure of maternal investment, which are likely buffered against perturbations in maternal condition.

Indexed as

Milk, HumanNutritional StatusBreast FeedingFemaleHumansImmunoglobulin GImmunologic FactorsInfantLactationMaleImmunoglobulin GImmunologic Factors

Identifiers

PMID37358306
PMCPMC10749986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.