ArticlemSystems2023
Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci.
Sruti DebRoy, William C Shropshire, Luis Vega, Chau Tran, Nicola Horstmann, Piyali Mukherjee, Selvalakshmi Selvaraj-Anand, Truc T Tran, Jordan Bremer, Marc Gohel and 3 more
Open access · goldAbstract read
In one paragraphArticle in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors at 3 institutions in 1 country.
Sruti DebRoyDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.ORCID 0000-0001-7328-0443 William C ShropshireDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.ORCID 0000-0001-8556-3248 Luis VegaDivision of Infectious Diseases and Department of Pediatrics, McGovern Medical School at UTHealth Houston and Children's Memorial Hermann Hospital , Houston, Texas, USA.
Chau TranDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Nicola HorstmannDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Piyali MukherjeeDivision of Infectious Diseases and Department of Pediatrics, McGovern Medical School at UTHealth Houston and Children's Memorial Hermann Hospital , Houston, Texas, USA.
Selvalakshmi Selvaraj-AnandSchool of Health Professions, The University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Truc T TranCenter for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas, USA.
Jordan BremerDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Marc GohelDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Cesar A AriasCenter for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas, USA.ORCID 0000-0001-9054-9774 Anthony R FloresDivision of Infectious Diseases and Department of Pediatrics, McGovern Medical School at UTHealth Houston and Children's Memorial Hermann Hospital , Houston, Texas, USA.ORCID 0000-0002-6402-4269 Samuel A ShelburneDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.ORCID 0000-0001-9721-263X The University of Texas MD Anderson Cancer Center · USMemorial Hermann · USHouston Methodist · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MProject 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0MRole of response regulator phosphorylation in group A streptococcal pathogenesisR01AI125292 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2017 to 2021
$2.0MTexas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3MRole of β-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant EnterobacteriaceaeR21AI151536 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2021 to 2022
$470kImpact of regulatory cross-talk on the pathophysiology of emergent acapsular group A streptococcusR21AI156202 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2021 to 2022
$446kNCI NIH HHS P30 CA016672NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI125292NIAID NIH HHS R21 AI151536NIAID NIH HHS R21 AI156202NIAID NIH HHS T32 AI141349
6 · The paper itselfAbstract
Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. Additionally, based on studies in
Indexed as
Bacterial ProteinsTranscriptomeHumansMutationPhenotypeStreptococcus pyogenesVirulenceBacterial ProteinsacapsularCovRSStreptococcus
Identifiers
PMID37358280
PMCPMC10470059
OpenAlexW4382010791
What OpenQuestion holds
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LicenceCC BY
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