ArticleACS nano2023
Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating.
Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
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- Conditional Reactivation of Lysozyme Nanosystems via Hydrophobic Ion Pairing.ACS nanoscience Au · 2026Article
- Magnetic nanoparticles as promising materials for the future of medicine.Journal of materials science. Materials in medicine · 2026Review
- Ferrimagnetic Vortex Nanorings Facilitate Efficient and Safe Deep-Brain Magnetothermal Stimulation in Freely Moving Mice.Exploration (Beijing, China) · 2025Article
- Recent Progress of Magnetic Nanomaterials with Enhanced Enzymatic Activities in Antitumor Therapy.International journal of molecular sciences · 2025Review
- NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging.ACS applied bio materials · 2025Article
- Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease.Asian journal of pharmaceutical sciences · 2024Review
- Novel Directed Enzyme Prodrug Therapy for Cancer Treatment Based on 2'-Deoxyribosyltransferase-Conjugated Magnetic Nanoparticles.Biomolecules · 2024Article
- Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy.RSC advances · 2024Article
- Biocatalyst immobilization on magnetic nano-architectures for potential applications in condensation reactions.Microbial biotechnology · 2024Review
- Biomimetic Sol-Gel Chemistry to Tailor Structure, Properties, and Functionality of Bionanocomposites by Biopolymers and Cells.Materials (Basel, Switzerland) · 2023Review
- pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy.RSC advances · 2023Article
- Stimuli-activatable nanomedicine meets cancer theranostics.Theranostics · 2023Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomimetic silica as an entrapment matrix was optimized to obtain nanosized hybrids (∼150 nm) for remote activation of the therapeutic enzyme. HRP converts indole-3-acetic acid (3IAA) into peroxylated radicals, whereas MNPs respond to alternating magnetic fields (AMFs) becoming local hotspots. The AMF application triggered an increase in the bioconversion rate of HRP matching the activity displayed at the optimal temperature of the nHs (
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Registered trials
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