ArticleThe Journal of antimicrobial chemotherapy2023
Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK.
Article in The Journal of antimicrobial chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 17 citations in OpenAlex.
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- Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea.Folia microbiologica · 2025Article
- Trimethoprim resistance inJournal of medical microbiology · 2025Article
- Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Antimicrobial Susceptibility Profiles ofAntibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial Susceptibility Profiles of CommensalAntibiotics (Basel, Switzerland) · 2024Article
- Variability in Profiles and Prevalences of Gram-Negative Bacteria in Urinary Tract Infections: A Population-Based Analysis.Journal of clinical medicine · 2024Article
- Global distribution and genetic characterization of blaWorld journal of microbiology & biotechnology · 2024Article
- Horizontal transfer characterization of ColV plasmids in blaPoultry science · 2024Article
- A review of the mechanisms that confer antibiotic resistance in pathotypes ofFrontiers in cellular and infection microbiology · 2024Review
- Gram negative bacteria related urinary tract infections: spectrum of antimicrobial resistance over 9 years in a University tertiary referral Hospital.Therapeutic advances in infectious diseaseArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundUrinary tract infections (UTIs) are a frequent cause for visits to primary care providers. In alignment globally, uropathogenic Escherichia coli (UPEC) are the main aetiological agent for UTIs in Norfolk and are increasingly difficult to treat due to multi-drug resistance.
objectivesWe set out to identify which clonal groups and resistance genes are disseminating in the community and hospitals in Norfolk, the first study of its kind for UPEC in this region.
methodsWe collected 199 clinical E. coli isolates causing UTIs in the community and hospital from the Clinical Microbiology laboratory at Norfolk and Norwich University Hospital between August 2021 and January 2022. These were whole-genome sequenced using the Illumina and MinION platforms for in silico MLST and antibiotic resistance determinant detection.
resultsThe isolates were composed of 70 STs; 8 lineages represented 56.7% of this population: ST73, ST12, ST69, ST131, ST404, ST95, ST127 and ST1193. Importantly, primary UTI screening deemed 6.5% of isolates to be multidrug resistant (MDR), with high rates of resistance to ampicillin (52.1%) and trimethoprim (36.2%) in hospitals. Of concern is the probable clonal expansion of MDR groups ST131 and ST1193 in hospitals and community settings with chromosomally encoded blaCTX-M-15, blaOXA-1 and aac(6')-Ib-cr5.
conclusionsThe burden of reported UTIs in Norfolk is largely caused by non-MDR isolates and mirrors similar UPEC studies nationally and internationally. Continually monitoring samples with consideration of sources will help reduce burden of disease.
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