Evidence map›Paper›PMID 37357776›Full record

ArticleCirculation. Cardiovascular interventions2023

Mediators of Improvement in TAVR Outcomes Over Time: Insights From the STS-ACC TVT Registry.

Suzanne V Arnold, Pratik Manandhar, Sreekanth Vemulapalli, Andrew M Vekstein, Andrzej S Kosinski, John D Carroll, Vinod H Thourani, Michael J Mack, David J Cohen

Abstract read
In one paragraph

Article in Circulation. Cardiovascular interventions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
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  3. Association of the CALLY Index With 30-Day Outcomes After Transcatheter Aortic Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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  14. Long-term outcomes of transapical-transcatheter aortic valve replacement.General thoracic and cardiovascular surgery · 2025
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suzanne V ArnoldSaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, MO (S.V.A.).ORCID 0000-0003-3367-0302
Pratik ManandharDuke University, Durham, NC (P.M., S.V., A.M.V., A.S.K.).
Sreekanth VemulapalliDuke University, Durham, NC (P.M., S.V., A.M.V., A.S.K.).ORCID 0000-0003-1599-2957
Andrew M VeksteinDuke University, Durham, NC (P.M., S.V., A.M.V., A.S.K.).
Andrzej S KosinskiDuke University, Durham, NC (P.M., S.V., A.M.V., A.S.K.).ORCID 0000-0003-4151-5185
John D CarrollUniversity of Colorado School of Medicine, Aurora (J.D.C.).
Vinod H ThouraniMarcus Heart and Valve Center, Piedmont Heart Institute, Atlanta, GA (V.H.T.).
Michael J MackBaylor Scott and White Health, Plano, TX (M.J.M.).ORCID 0000-0002-3148-9158
David J CohenSt. Francis Hospital, Roslyn, NY (D.J.C.).ORCID 0000-0001-9163-724X

Funding

Optimal Decision Making in Aortic Valve ReplacementK23HL116799 · NHLBI · SAINT LUKE'S HOSPITAL · PI ARNOLD, SUZANNE VICTORIA · 2014 to 2018
$635k
NHLBI NIH HHS K23 HL116799
6 · The paper itself

Abstract

backgroundOver the past decade, there has been substantial improvement in outcomes after transcatheter aortic valve replacement. Many patient and procedural factors have also changed over that time, making it challenging to untangle the drivers of those improvements.

methodsAmong patients who underwent transcatheter aortic valve replacement from 2012 to 2018 within the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry, we examined the relative contribution of changes in patient factors, device modifications, improving experience/skill, and advances in periprocedural care to the observed improvement in outcomes after transcatheter aortic valve replacement. Mediator clusters included demographics, noncardiovascular comorbidities, cardiovascular comorbidities, device-related factors, and nondevice-related procedural factors. Using logistic regression, we serially adjusted for the mediator clusters to examine the contribution of each to the observed improvement in outcomes over time.

resultsAmong 161 196 patients treated with transcatheter aortic valve replacement at 596 sites, outcomes improved steadily from 2012 to 2018, including 30-day mortality (6.7% to 2.4%), 30-day composite adverse events (25.3% to 10.5%), and 1-year mortality (19.9% to 10.1%; all

conclusionsWhile US patients undergoing transcatheter aortic valve replacement have become younger, healthier, and lower risk over time, the most important factors contributing to improvements in short-term outcomes relate to advances in device technology and procedural factors, whereas changing patient characteristics had a greater impact on improvement in 1-year outcomes.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAortic ValveHumansRegistriesRisk FactorsTreatment OutcomeUnited Statesoutcomesquality improvementregistriestranscatheter aortic valve replacement

Identifiers

PMID37357776
PMCPMC10527153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.