ArticleCurrent organic synthesis2024
Synthesis and Cytotoxic Activity of Quinazoline-benzofuran Conjugates.
Article in Current organic synthesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimsIn order to study on structure-activity relationships of benzofurans.
backgroundBenzofuran is a kind of natural compound widely existing in nature with pharmacological effects. The development of new anticancer benzofuran derivatives has attracted more and more attention.
methodsWe have introduced an active quinazoline unit into piperazine-substituted benzofuran, prepared a series of quinazoline-benzofuran compounds, and evaluated cytotoxic activity against a panel of human tumor cell lines by MTT assay.
results48 novel quinazoline-substituted benzofuran derivatives have been prepared, and
conclusionWe have found that compound 14x displayed excellent cytotoxic activity, which could be considered a potential anticancer agent.
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