ArticleThe journal of nutrition, health & aging2023
Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011-2014.
Article in The journal of nutrition, health & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention.The journal of nutrition, health & aging · 2024Trial
- Early-life GABA-A receptor blockade with bicuculline attenuates anxiety-like behaviors and cognitive deficits induced by 24-hr sleep deprivation in adult male rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
- Associations of Dietary Antioxidant and Phytochemical Indices with Cognitive Function: Mediating Roles of Basal Metabolic Rate and Systemic Inflammation.Antioxidants (Basel, Switzerland) · 2026Article
- Nonlinear L-shaped association between composite dietary antioxidant index and risk of dementia: a prospective cohort study.Frontiers in public health · 2026Article
- Article
- The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003-2010.Biogerontology · 2025Article
- Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels.Frontiers in nutrition · 2025Article
- Dietary total antioxidant capacity and frailty in Turkish community-dwelling and nursing home: cross-sectional study.Frontiers in medicine · 2025Article
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- Article
- Association between the composite dietary antioxidant index and erectile dysfunction in US men: a cross-sectional study.Journal of health, population, and nutrition · 2024Article
- Association of oxidative balance score with Helicobacter pylori infection and mortality among US population.European journal of nutrition · 2024Article
- Association between vitamin B2 intake and cognitive performance among older adults: a cross-sectional study from NHANES.Scientific reports · 2024Article
- The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration:Antioxidants (Basel, Switzerland) · 2024Review
- The role of composite dietary antioxidants in elderly cognitive function: insights from NHANES.Frontiers in nutrition · 2024Article
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10 authors.
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Abstract
objectivesOxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function of older adults in the U.S.
designA cross-sectional study.
settingNational Health and Nutrition Examination Surveys database.
participants2712 older adults aged over 60 years. MEASUREMENTS: TAC was calculated from 8 antioxidative vitamins based on the reference values for vitamin C equivalent antioxidant capacity obtained from individuals' 24 h dietary recall. Four memory-related assessments were employed [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)].
resultsAmong the 2712 participants, the median age was 68 years, and 50.4% were women. Participants in the group with higher TAC levels had relatively higher IRT, AFT and DSST scores (P=0.025, P=0.008, P<0.001, respectively). In adjusted weighted linear regression, log-transformed TAC was positively associated with AFT (β=1.10, 95%CI: 0.51, 1.70) and DSST (β=2.81, 95%CI: 1.16, 4.45). Compared with the first quartile, the participants in the second (Q2 vs. Q1, OR=0.66, 95%CI: 0.43,1.02) and fourth quartile (Q4 vs. Q1, OR=0.47, 95%CI:0.28, 0.78) of log-transformed TAC showed a decreased risk of impaired cognitive function (ICF) after adjusting for confounders. The dose-response analysis indicated a gradual descent in the risk of ICF as TAC increases. Diabetes mellitus (DM) mediated part of the effect of TAC on ICF. The relationship between TAC and ICF was more pronounced in subjects with DM (Q4 vs Q1, OR=0.36, 95%CI:0.17, 0.74).
conclusionOur findings support that higher dietary antioxidant potential was related to a decreased risk of cognitive dysfunction, particularly in the subjects with DM who may have oxidative injury. DM was one of the factors mediating the effect of TAC on ICF.
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