ArticleLight, science & applications2023
Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism.
Article in Light, science & applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role of stereochemistry on electron transport in peptides.bioRxiv : the preprint server for biology · 2026Article
- Helicity-selective and spectrally tunable chiral thermal emissions.Nature communications · 2026Article
- Bound states in the continuum: From fundamental physics to emerging photonic paradigms.iScience · 2026Review
- Mid-infrared chirality and chiral thermal emission from twisted α-MoONature communications · 2025Article
- Ultrasensitive and Tunable Achiral Metamaterial Substrates as Nanobiosensors for Enantiomer Detection.ACS applied materials & interfaces · 2025Article
- Chiral Materials: Multidisciplinary Progress and Emerging Frontier Application Prospects.Nanomaterials (Basel, Switzerland) · 2025Review
- AI‑driven photonic noses: from conventional sensors to cloud‑to-edge intelligent microsystems.Microsystems & nanoengineering · 2025Review
- Geometric Analysis and Experimental Studies of Hexachiral Structures.Materials (Basel, Switzerland) · 2025Article
- Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs.Scientific reports · 2025Article
- Surface-enhanced spectroscopy technology based on metamaterials.Microsystems & nanoengineering · 2025Review
- Unraveling the Growth Mechanism of Chiral Inorganic Nanocrystals via High-Resolution Electron Microscopy.Journal of the American Chemical Society · 2024Article
- Advances and Applications of Metal-Organic Frameworks (MOFs) in Emerging Technologies: A Comprehensive Review.Global challenges (Hoboken, NJ) · 2024Review
- Vibrational circular dichroism unveils hidden clues.Light, science & applications · 2023Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
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Authors and funding
7 authors.
Funding
Abstract
Circular dichroism (CD) spectroscopy has been widely demonstrated for detecting chiral molecules. However, the determination of chiral mixtures with various concentrations and enantiomeric ratios can be a challenging task. To solve this problem, we report an enhanced vibrational circular dichroism (VCD) sensing platform based on plasmonic chiral metamaterials, which presents a 6-magnitude signal enhancement with a selectivity of chiral molecules. Guided by coupled-mode theory, we leverage both in-plane and out-of-plane symmetry-breaking structures for chiral metamaterial design enabled by a two-step lithography process, which increases the near-field coupling strengths and varies the ratio between absorption and radiation loss, resulting in improved chiral light-matter interaction and enhanced molecular VCD signals. Besides, we demonstrate the thin-film sensing process of BSA and β-lactoglobulin proteins, which contain secondary structures α-helix and β-sheet and achieve a limit of detection down to zeptomole level. Furthermore, we also, for the first time, explore the potential of enhanced VCD spectroscopy by demonstrating a selective sensing process of chiral mixtures, where the mixing ratio can be successfully differentiated with our proposed chiral metamaterials. Our findings improve the sensing signal of molecules and expand the extractable information, paving the way toward label-free, compact, small-volume chiral molecule detection for stereochemical and clinical diagnosis applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.