Evidence map›Paper›PMID 37356812›Full record

ArticleJornal de pediatria

The risks of the new morbidities acquired during pediatric onco-critical care and their life-shortening effects.

Gabriela Maria Virgílio Dias Santos, Orlei Ribeiro de Araujo, Priscila de Biasi Leal, Rodrigo Genaro Arduini, Rosa Massa Kikuchi de Sousa, Eliana Maria Monteiro Caran, Dafne Cardoso Bourguignon da Silva

Open access · goldAbstract read
In one paragraph

Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Out of the PICU and Beyond!Jornal de pediatria
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gabriela Maria Virgílio Dias SantosGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil.
Orlei Ribeiro de AraujoGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil. Electronic address: orlei@uol.com.br.
Priscila de Biasi LealGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil.
Rodrigo Genaro ArduiniGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil.
Rosa Massa Kikuchi de SousaGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil.
Eliana Maria Monteiro CaranUniversidade Federal de São Paulo (UNIFESP), Departamento de Pediatria, São Paulo, SP, Brazil; Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Departamento de Oncologia, São Paulo, SP, Brazil.
Dafne Cardoso Bourguignon da SilvaGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Unidade de Tratamento Intensivo, São Paulo, SP, Brazil.
Support group for adolescents and children with cancer · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe authors investigated the functional status at ICU admission and at hospital discharge, and the impact of dysfunctions on survivors' lifespan.

methodSingle-center retrospective cohort. The FSS (Functional Status Scale) was calculated at ICU admission and at hospital discharge. A new morbidity was defined as an increase in FSS ≥ 3.

resultsAmong 1002 patients, there were 855 survivors. Of these, 194 (22.6%) had died by the end of the study; 45 (5.3%) had a new morbidity. Means in the motor domain at admission and discharge were 1.37 (SD: 0.82) and 1.53 (SD 0.95, p = 0.002). In the feeding domain, the means were 1.19 (SD 0.63) and 1.30 (SD 0.76), p = 0.002; global means were 6.93 (SD 2.45) and 7.2 (SD 2.94), p = 0.007.  Acute respiratory failure requiring mechanical ventilation, the score PRISM IV, age < 5 years, and central nervous system tumors were independent predictors of new morbidity. New morbidity correlated with lower odds of survival after hospital discharge, considering all causes of death (p = 0.014), and was independently predictive of death (Cox hazard ratio = 1.98). In Weibull models, shortening in the life span of 14.2% (p = 0.014) was estimated as a new morbidity.

conclusionsNew morbidities are related to age, disease severity at admission, and SNC tumors. New morbidities, in turn, correlate with lower probabilities of survival and shortening of the remaining life span. Physical rehabilitation interventions in this population of children may have the potential to provide an increase in lifespan.

Indexed as

Critical CareHospitalizationChildChild, PreschoolHumansMorbidityPatient DischargeRetrospective StudiesCancer survivor, childhoodCritical care outcomesExpectancy, healthy lifeFunctional status

Identifiers

PMID37356812
PMCPMC10594009
OpenAlexW4381681822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.