Identifying Adult Stomach Tissue Stem/Progenitor Cells Using the Iqgap3-2A-CreERT2 Mouse.

Junichi Matsuo, Linda Shyue Huey Chuang, Jasmine Jie Lin Tong, Daisuke Douchi, Yoshiaki Ito

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.4field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases.International journal of molecular sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Junichi MatsuoCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Linda Shyue Huey ChuangCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Jasmine Jie Lin TongCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Daisuke DouchiCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Yoshiaki ItoCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. yoshi_ito@nus.edu.sg.

National University Cancer Institute, Singapore · SGNational University of Singapore · SGTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of unique gene markers of normal and cancer stem cells is an effective strategy to study cells of origin and understand tumor behavior. Lineage tracing experiments using the Cre recombinase driven by a stem cell-specific promoter in the CreERT2 reporter mouse model enables identification of adult stem cells and delineation of stem cell activities in vivo. In our recent research on the mouse stomach, Iqgap3 was identified as a homeostatic stem cell marker located in the isthmus of the stomach epithelium. Lineage tracing with the Iqgap3-2A-CreERT2;Rosa26-LSL-tdTomato mouse model demonstrated stem cell activity in Iqgap3-expressing cells. Using the Iqgap3-2A-CreERT2 mouse model to target oncogenic Kras

Indexed as

Adult Stem CellsStomach NeoplasmsAnimalsGastric MucosaMiceMice, TransgenicNeoplastic Stem CellsProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins p21(ras)CarcinogenesisIqgap3KrasG12DLineage tracingMetaplasiaMouse modelStem cellsStomach

Identifiers

PMID37355533

DOI10.1038/s41392-021-00780-4

OpenAlexW4381888396

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.