Evidence map›Paper›PMID 37355531›Full record

ArticleJournal of autism and developmental disorders2024

Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.

Linn Andersson Konke, Terje Falck-Ytter, Emily J H Jones, Amy Goodwin, Karin Brocki

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Linn Andersson KonkeDepartment of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden. linn.andersson.konke@psyk.uu.se.ORCID http://orcid.org/0000-0003-4189-1690
Terje Falck-YtterDepartment of Women's and Children's Health, Karolinska Institutet Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9714-0197
Emily J H JonesCenter for Brain and Cognitive Development, Birkbeck, University of London, London, UK.ORCID https://orcid.org/0000-0001-5747-9540
Amy GoodwinDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0003-2585-8452
Karin BrockiDepartment of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-4310-3224
Uppsala University · SEBirkbeck, University of London · GBKing's College London · GB

Funding

Autistica BASIS funding consortiumFP7 Joint Research Centre FP/2007-2013Medical Research Council G0701484Medical Research Council MR/K021389/1Medical Research Council MR/T003057/1MQ: Transforming Mental Health MQ14PP83MRF G0701484MRF MR/K021389/1Riksbankens Jubileumsfond NHS14-1802:1
6 · The paper itself

Abstract

The purpose of the current study was to use the infant sibling design to explore whether proband traits of autism and ADHD could provide information about their infant sibling's temperament. This could help us to gain information about the extent to which infant temperament traits are differentially associated with autism and ADHD traits. We used parent-ratings of autistic traits and ADHD traits (CRS-3) in older siblings diagnosed with autism (age range 4 to 19 years), and their infant siblings' temperament traits (IBQ) at 9 months of age in 216 sibling pairs from two sites (BASIS, UK, and EASE, Sweden) to examine associations across siblings. We found specific, but modest, associations across siblings after controlling for sex, age, developmental level and site. Proband autistic traits were specifically related to low levels of approach in the infant siblings, with infant developmental level explaining part of the variance in infant approach. Proband ADHD traits were specifically related to high levels of infant activity even after controlling for covariates. Our findings suggest that proband traits of autism and ADHD carry information for infant sibling's temperament, indicating that inherited liability may influence early emerging behaviours in infant siblings. The impact of sex, age, developmental level and site are discussed.

Indexed as

Attention Deficit Disorder with HyperactivitySiblingsTemperamentAdolescentAutistic DisorderChildChild, PreschoolFemaleHumansInfantMaleSwedenYoung AdultAttention-deficit/hyperactivity disorderAutism spectrum disorderDevelopmental substructureEtiologyTemperament

Identifiers

PMID37355531
PMCPMC11362528
OpenAlexW4381943591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.