Evidence map›Paper›PMID 37355265›Full record

ArticleBMJ open2023

Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach.

Masatoshi Yamashita, Kuriko Kagitani-Shimono, Yoshiyuki Hirano, Sayo Hamatani, Shota Nishitani, Akiko Yao, Sawa Kurata, Hirotaka Kosaka, Minyoung Jung, Tokiko Yoshida and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Masatoshi YamashitaResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Kuriko Kagitani-ShimonoUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Yoshiyuki HiranoUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.ORCID 0000-0003-3844-3061
Sayo HamataniResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Shota NishitaniResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Akiko YaoResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Sawa KurataResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Hirotaka KosakaResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Minyoung JungUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Tokiko YoshidaResearch Centre for Child Mental Development, Chiba University, Chiba, Japan.
Tsuyoshi SasakiDepartment of Child Psychiatry and Psychiatry, Chiba University Hospital, Chiba, Japan.
Koji MatsumotoDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Yoko KatoDepartment of Paediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
Mariko NakanishiUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Masaya TachibanaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Ikuko MohriUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Kenji J TsuchiyaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Tetsuya TsujikawaDepartment of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Hidehiko OkazawaBiomedical Imaging Research Centre, University of Fukui, Fukui, Japan.
Eiji ShimizuUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Masako TaniikeUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Akemi TomodaResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan.
Yoshifumi MizunoResearch Centre for Child Mental Development, University of Fukui, Fukui, Japan mizunoy@u-fukui.ac.jp.ORCID 0000-0003-2209-352X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures. METHODS AND ANALYSIS: We will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD. ETHICS AND DISSEMINATION: The study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAdultBrainChildCross-Sectional StudiesHumansMagnetic Resonance ImagingMulticenter Studies as TopicChild & adolescent psychiatryDevelopmental neurology & neurodisabilityPaediatric neurology

Identifiers

PMID37355265
PMCPMC10314540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.