Evidence map›Paper›PMID 37354364›Full record

Trial reportMaternal and child health journal2023

Treatment of Perinatal Depression and Correlates of Treatment Response Among Pregnant Women Living with HIV in Uganda.

Laura J Faherty, Violet Gwokyalya, Akena Dickens, Ryan McBain, Vicky Ngo, Janet Nakigudde, Juliet Nakku, Barbara Mukasa, Jolly Beyeza-Kashesya, Rhoda K Wanyenze and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal and child health journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Laura J FahertyRAND Corporation, 20 Park Plaza, Suite 920, Boston, MA, 02128, USA. lfaherty@rand.org.ORCID http://orcid.org/0000-0002-8953-8856
Violet GwokyalyaMakerere University, 7062 University Rd, Kampala, Uganda.
Akena DickensMakerere University, 7062 University Rd, Kampala, Uganda.
Ryan McBainRAND Corporation, 20 Park Plaza, Suite 920, Boston, MA, 02128, USA.
Vicky NgoGraduate School of Public Health and Health Policy, City University of New York, 205 E 42nd St, New York, NY, 10017, USA.
Janet NakiguddeMakerere University, 7062 University Rd, Kampala, Uganda.
Juliet NakkuMakerere University, 7062 University Rd, Kampala, Uganda.
Barbara MukasaMildmay Uganda, P.O Box 24985, Kampala, Uganda.
Jolly Beyeza-KashesyaMakerere University, 7062 University Rd, Kampala, Uganda.
Rhoda K WanyenzeMakerere University, 7062 University Rd, Kampala, Uganda.
Glenn J WagnerRAND Corporation, 1776 Main St, Santa Monica, CA, 90407, USA.
Makerere University · UGRAND Corporation · USCity University of New York · USMildmay Uganda · UG

Funding

Depression Care to Improve Adherence to PMTCT Care Continuum & Pregnancy OutcomesR01MH115830 · NIMH · RAND CORPORATION · PI WAGNER, GLENN JOHN · 2018 to 2022
$3.1M
NIMH NIH HHS R01 MH115830
6 · The paper itself

Abstract

introductionPerinatal depression is common among women living with HIV, but depression care is limited in low-resource settings. We examined (1) characteristics of women receiving Problem Solving Therapy (PST) versus antidepressant therapy (ADT), (2) treatment response by modality, and (3) correlates of treatment response.

methodsThis analysis used data from 191 Ugandan women in the intervention arm of a cluster randomized controlled trial of task-shifted, stepped-care depression treatment for pregnant women living with HIV (PWLWH). Treatment response was defined as scoring < 5 on the nine-item Patient Health Questionnaire (PHQ-9). Bivariate analysis and multivariable logistic regression were used to examine characteristics of women by treatment group and correlates of treatment response.

resultsOf 134 participants with depression, 129 (96%) were treated: 84 (65%) received PST and 45 (35%) received ADT. Severe depression at treatment initiation was more common in those receiving ADT (28.9% versus 4.8%, Fischer's Exact Test < 0.001). Treatment response was higher for PST (70/84; 83.3%) than ADT (30/45; 66.7%; p = .03). ADT side effects were rare and minor; no infants had serious congenital defects. Of 22 participants (19%) who did not respond to treatment, only five received intensified management. Social support and interpersonal violence were associated with treatment response (adjusted odds ratio, [aOR] = 3.06, 95% CI = 1.08-8.66 and aOR = 0.64, 95% CI = 0.44-0.93). DISCUSSION: Both depression treatment modalities yielded high response rates in Ugandan PWLWH; ADT was well-tolerated. Our results highlight a need to build capacity to implement the stepped-care protocol for non-responders and screen for social support and interpersonal violence.

Indexed as

HIV InfectionsPregnant PeopleDepressionFemaleHumansPregnancySurveys and QuestionnairesUgandaAntidepressantsDepressionHIVPerinatalPMTCTProblem Solving TherapyUganda

Identifiers

PMID37354364
PMCPMC10564822
OpenAlexW4381855790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.