Evidence map›Paper›PMID 37354339›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Evaluation of cervical lymph nodes using multispectral optoacoustic tomography: a proof-of-concept study.

Christoph Becker, Johannes Hardarson, Andrea Hoelzer, Antje Geisler, Tobias Schulz, Charlène Reichl, Neil C Burton, Tobias Schuler, Peter Kohl, Callum Zgierski-Johnston

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christoph BeckerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany. christoph.becker@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-8385-0785
Johannes HardarsonDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Andrea HoelzerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Antje GeislerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Tobias SchulzDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Charlène ReichliThera Medical GmbH, 81379, Munich, Germany.
Neil C BurtoniThera Medical GmbH, 81379, Munich, Germany.
Tobias SchulerInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany.
Peter KohlInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany.
Callum Zgierski-JohnstonInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany.
University of Freiburg · DEiThera Medical (Germany) · DEUniversity Medical Center Freiburg · DE

Funding

Deutsche Forschungsgemeinschaft 422681845Deutsche Gesellschaft für Ultraschall in der Medizin
6 · The paper itself

Abstract

objectivesExamination of lymph nodes is one of the most common indications for imaging in the head and neck region. The purpose of this study is to evaluate whether multispectral optoacoustic tomography can be used to observe chromophore differences between benign and malignant neck lymph nodes. MATERIALS AND

methodsProof-of-concept ex vivo study of resected cervical lymph nodes from 11 patients. The examination of lymph nodes included imaging with hybrid ultrasound and multispectral tomography system followed by spectral unmixing to separate signals from the endogenous chromophores water, lipid, hemoglobin and oxygenated hemoglobin; calculation of semi-quantitative parameters (total hemoglobin and relative oxygenation of hemoglobin). Comparison of the results from the hybrid measurement with the histopathological results.

resultsMost patients suffered from squamous cell carcinoma (n = 7), also metastasis from salivary gland adenocarcinoma and papillary thyroid carcinoma, were included. The comparison between benign cervical lymph nodes and metastases showed significant differences for the absorbers water, lipid, hemoglobin and oxygenated hemoglobin and total hemoglobin.

conclusionsOur ex vivo study suggests that multispectral optoacoustic tomography can be used to detect differences between reactive lymph nodes and metastases. The measurement of endogenous chromophores can be used for this purpose. The examinations are non-invasively and thus potentially improve diagnostic prediction. However, potential influences from the ex vivo setting must be considered.

Indexed as

Lymph NodesThyroid NeoplasmsHemoglobinsHumansLipidsTomographyHemoglobinsLipidsHead and neck cancerLymph nodeMetastasisMultispectral optoacoustic tomographyOptical imagingOptoacoustic imagingSalivary glandThyroid gland

Identifiers

PMID37354339
PMCPMC10477228
OpenAlexW4381856221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.