Evidence map›Paper›PMID 37354317›Full record

ArticleApoptosis : an international journal on programmed cell death2023

Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice.

Xiaofei Fan, Xiaoyu Wang, Yangyang Hui, Tianming Zhao, Lihong Mao, Binxin Cui, Weilong Zhong, Chao Sun

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaofei Fan *Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Xiaoyu Wang *Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Yangyang Hui *Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Tianming ZhaoDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Zhongshan Road 321,Gulou District, Nanjing, 210008, Jiangsu, China.
Lihong MaoDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Binxin CuiDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Weilong ZhongDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China.
Chao SunDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, 300052, China. chaosun@tmu.edu.cn.ORCID 0000-0002-0380-7999
Tianjin Medical University General Hospital · CNNanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is essential to further characterize liver injury aimed at developing novel therapeutic approaches. This study investigated the mechanistic basis of genipin against carbon tetrachloride (CCl

Indexed as

Arachidonate 15-LipoxygenaseChemical and Drug Induced Liver InjuryFerroptosisIridoidsLipid PeroxidationPhospholipid Hydroperoxide Glutathione PeroxidaseProtective AgentsAnimalsArachidonate 12-LipoxygenaseCarbon TetrachlorideCyclohexylaminesHepatocytesHumansLiverMaleMiceAlox15 protein, mouseArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseCarbon TetrachlorideCyclohexylaminesferrostatin-1genipinglutathione peroxidase 4, mouseIridoidsPhenylenediaminesPhospholipid Hydroperoxide Glutathione PeroxidaseProtective AgentsArachidonate 15-lipoxygenaseFerroptosisGenipinGPX4Liver injury

Identifiers

PMID37354317
OpenAlexW4381890881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.