Evidence map›Paper›PMID 37354236›Full record

SynthesisArchives of gynecology and obstetrics2024

Fertility, pregnancy and perioperative outcomes after operative hysteroscopy for uterine septum: a network meta-analysis.

Dimitrios Rafail Kalaitzopoulos, Maria Zografou Themeli, Georgios Grigoriadis, Maurizio D Alterio, Salvatore Giovanni Vitale, Stefano Angioni, Angelos Daniilidis

Registry-linked trialAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06315582 (Surgical Approach to Uterine Septum), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06315582 narecruitingnot on this map

Surgical Approach to Uterine Septum: A Randomized Controlled Trial

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2026Enrolled40ConditionsUterine Septum, Surgical Complication, Septum, UterusArmsRemoval of uterine septum with hysteroscopic scissors without electrosurgery., Hysteroscopic septoplasty utilizing bipolar electrosurgery
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Dimitrios Rafail KalaitzopoulosDepartment of Obstetric and Gynecology, Cantonal Hospital of Schaffhausen, Geissbergstrasse 81, 8208, Schaffhausen, Switzerland. dimkal1991@windowslive.com.ORCID 0000-0002-8053-1308
Maria Zografou ThemeliDepartment of Obstetrics and Gynecology, Evangelisches Krankenhaus Oberhausen, Virchowstrasse 20, 46047, Oberhausen, Germany.
Georgios Grigoriadis2nd University Department in Obstetrics and Gynecology, School of Medicine, Hippokratio General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Maurizio D AlterioUniversity Department in Obstetrics and Gynecology, University of Cagliari, Cagliari, Italy.
Salvatore Giovanni VitaleUniversity Department in Obstetrics and Gynecology, University of Cagliari, Cagliari, Italy.
Stefano AngioniUniversity Department in Obstetrics and Gynecology, University of Cagliari, Cagliari, Italy.
Angelos Daniilidis1st University Department in Obstetrics and Gynecology, School of Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
University of Cagliari · ITAristotle University of Thessaloniki · GREvangelisches Krankenhaus Oberhausen · DESpitäler Schaffhausen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeptate uterus is a congenital malformation associated with adverse reproductive and pregnancy outcomes. It remains controversial whether hysteroscopic septoplasty should be recommended for the treatment of septate uterus, and it is also unclear if different hysteroscopic methods have more favorable outcomes. This study aims to compare the available hysteroscopic techniques of septoplasty for fertility, reproductive, and perioperative outcomes.

methodsThis systematic review and meta-analysis was conducted following PRISMA guidelines. We searched Medline, Scopus, and Cochrane databases up to April 2023 without language restrictions. Eligible studies had to compare two or more different methods of hysteroscopic septoplasty in women with septate uterus and report on fertility and pregnancy outcomes after a follow-up. Perioperative outcomes were also examined. Data extraction was performed by two independent reviewers using a standardized form. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Form and Revised Cochrane risk-of-bias tool (RoB 2).

resultsOut of 561 studies identified, 9 were included in the systematic review and meta-analysis. The comparison of different hysteroscopic septoplasty techniques based on the energy used showed higher pregnancy rates after mechanical septoplasty in comparison to electrosurgery, while miscarriage and live birth rates were comparable. Laser vs. electrosurgery and mechanical techniques of septoplasty had comparable pregnancy, miscarriage, and live birth rates. The network meta-analysis after comparing every different method used showed significantly higher clinical pregnancy rate in scissor group in comparison to resectoscope. No significant differences were found among the techniques regarding miscarriage rate and live birth rate.

conclusionIn summary, this systematic review and network meta-analysis suggests that hysteroscopic septoplasty with scissors is associated with higher pregnancy rates compared to resectoscope. However, the limited evidence available and small sample sizes in the included studies indicate that these findings should be interpreted with caution. Further studies are required to determine the effectiveness of various hysteroscopic techniques and guide clinical decision-making in the management of this condition.

Indexed as

HysteroscopyPregnancy RateSeptate UterusElectrosurgeryFemaleFertilityHumansPregnancyPregnancy OutcomeUterusHysteroscopyInfertilityPregnancySeptate uterus

Identifiers

PMID37354236
OpenAlexW4381890829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.