Evidence map›Paper›PMID 37354235›Full record

ArticleCell and tissue research2023

Comparative study of calcification in human choroid plexus, pineal gland, and habenula.

O Junemann, A G Ivanova, I Bukreeva, D A Zolotov, M Fratini, A Cedola, F Wilde, I G Dyachkova, Yu S Krivonosov, D A Otlyga and 1 more

Abstract read
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Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

O JunemannInstitute of Nanotechnology-CNR (Rome unit), c/o Department of Physics, La Sapienza University, Piazzale Aldo Moro 5, Rome, Italy. junemann@outlook.com.ORCID http://orcid.org/0000-0001-5828-5393
A G IvanovaFederal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Leninskiy Prospekt 59, Moscow, Russian Federation.
I BukreevaInstitute of Nanotechnology-CNR (Rome unit), c/o Department of Physics, La Sapienza University, Piazzale Aldo Moro 5, Rome, Italy. inna.bukreeva@cnr.it.
D A ZolotovFederal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Leninskiy Prospekt 59, Moscow, Russian Federation.
M FratiniInstitute of Nanotechnology-CNR (Rome unit), c/o Department of Physics, La Sapienza University, Piazzale Aldo Moro 5, Rome, Italy.
A CedolaInstitute of Nanotechnology-CNR (Rome unit), c/o Department of Physics, La Sapienza University, Piazzale Aldo Moro 5, Rome, Italy.
F WildeInstitute of Materials Physics, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, Germany.
I G DyachkovaFederal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Leninskiy Prospekt 59, Moscow, Russian Federation.
Yu S KrivonosovFederal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Leninskiy Prospekt 59, Moscow, Russian Federation.
D A OtlygaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Tsyurupy Street, 3, Moscow, Russian Federation.
S V SavelievAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Tsyurupy Street, 3, Moscow, Russian Federation.
Russian Academy of Sciences · RUResearch Institute of Human Morphology · RUSapienza University of Rome · ITFondazione Santa Lucia · ITHelmholtz-Zentrum Hereon · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choroid plexus, pineal gland, and habenula tend to accumulate physiologic calcifications (concrements) over a lifetime. However, until now the composition and causes of the intracranial calcifications remain unclear. The detailed analysis of concrements has been done by us using X-ray diffraction analysis (XRD), X-ray diffraction topography (XRDT), micro-CT, X-ray phase-contrast tomography (XPCT), as well as histology and immunohistochemistry (IHC). By combining physical (XRD) and biochemical (IHC) methods, we identified inorganic (hydroxyapatite) and organic (vimentin) components of the concrements. Via XPCT, XRDT, histological, and IHC methods, we assessed the structure of concrements within their appropriate tissue environment in both two and three dimensions. The study found that hydroxyapatite was a major component of all calcified depositions. It should be noted, however, that the concrements displayed distinctive characteristics corresponding to each specific structure of the brain. As a result, our study provides a basis for assessing the pathological and physiological changes that occur in brain structure containing calcifications.

Indexed as

CalcinosisHabenulaPineal GlandCalcification, PhysiologicChoroid PlexusHumansHydroxyapatitesX-Ray MicrotomographyHydroxyapatitesChoroid plexusHabenulaImmunohistochemistryPineal glandX-ray diffraction analysisX-ray phase contrast tomography

Identifiers

PMID37354235
OpenAlexW4381890919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.