Evidence map›Paper›PMID 37353996›Full record

SynthesisCancer medicine2023

A systematic review and meta-analysis of predictive and prognostic models for outcome prediction using positron emission tomography radiomics in head and neck squamous cell carcinoma patients.

Mahima Merin Philip, Andy Welch, Fergus McKiddie, Mintu Nath

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Predictive Value of [Journal of clinical medicine · 2025
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  12. Role ofCancers · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahima Merin PhilipInstitute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Andy WelchInstitute of Education in Healthcare and Medical Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-6350-0673
Fergus McKiddieNational Health Service Grampian, Aberdeen, UK.
Mintu NathInstitute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-0753-0464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositron emission tomography (PET) images of head and neck squamous cell carcinoma (HNSCC) patients can assess the functional and biochemical processes at cellular levels. Therefore, PET radiomics-based prediction and prognostic models have the potentials to understand tumour heterogeneity and assist clinicians with diagnosis, prognosis and management of the disease. We conducted a systematic review of published modelling information to evaluate the usefulness of PET radiomics in the prediction and prognosis of HNSCC patients.

methodsWe searched bibliographic databases (MEDLINE, Embase, Web of Science) from 2010 to 2021 and considered 31 studies with pre-defined inclusion criteria. We followed the CHARMS checklist for data extraction and performed quality assessment using the PROBAST tool. We conducted a meta-analysis to estimate the accuracy of the prediction and prognostic models using the diagnostic odds ratio (DOR) and average C-statistic, respectively.

resultsManual segmentation method followed by 40% of the maximum standardised uptake value (SUV

conclusionsBoth prediction and prognostic models using clinical variables and PET radiomics demonstrated reliable accuracy for detecting adverse outcomes in HNSCC, suggesting the prospect of PET radiomics in clinical settings for diagnosis, prognosis and management of HNSCC patients. Future studies of prediction and prognostic models should emphasise the quality of reporting, external model validation, generalisability to real clinical scenarios and enhanced reproducibility of results.

Indexed as

Head and Neck NeoplasmsPositron-Emission TomographyFluorodeoxyglucose F18HumansPrognosisReproducibility of ResultsSquamous Cell Carcinoma of Head and NeckFluorodeoxyglucose F18head and neck squamous cell carcinomapositron emission tomographyprognosisradiomicssystematic review

Identifiers

PMID37353996
PMCPMC10469753

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.