ArticleBMC neurology2023
A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli.
Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Research progress on occupational therapy for disorders of consciousness in the context of neurorehabilitation: visual analysis based on CiteSpace.Frontiers in neurologyPooled it
- Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS.GeroScience · 2026Article
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Multimodal biomarkers of response to transcutaneous auricular vagus nerve stimulation in disorders of consciousness: a study protocol.Frontiers in human neuroscience · 2026Article
- Sensitive and specific fNIRS-based approach for awareness detection in disorders of consciousness: proof of principle in healthy adults.Neurophotonics · 2025Article
- Hemodynamic responses to emotional auditory stimuli in patients with prolonged disorders of consciousness: an fNIRS study.Frontiers in neurology · 2025Article
- Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness.Frontiers in neurology · 2025Review
- Case report: Monitoring consciousness with fNIRS in a patient with prolonged reduced consciousness following hemorrhagic stroke undergoing adjunct taVNS therapy.Frontiers in neuroscience · 2025Article
- Evaluating Brain Activity in Patients With Chronic Disorders of Consciousness After Traumatic Brain Injury Using EEG Microstate Analysis During Hyperbaric Oxygen Therapy.CNS neuroscience & therapeutics · 2025Article
- Assessment of residual awareness in patients with disorders of consciousness using functional near-infrared spectroscopy-based connectivity: a pilot study.Neurophotonics · 2024Article
- Brain cortex activity of patients with disorders of consciousness under familiar and unfamiliar voice of subject's own name: an fNIRS-based study.Frontiers in neurologyArticle
- Towards the use of functional near-infrared spectroscopy as an assessment tool in disorders of consciousness.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Treating prolonged disorders of consciousness (pDoC) is challenging. Thus, accurate assessment of residual consciousness in patients with pDoC is important for the management and recovery of patients. Functional near-infrared spectroscopy (fNIRS) can be used to detect brain activity through changes of oxygenated hemoglobin/deoxygenated hemoglobin (HbO/HbR) concentrations changes and has recently gained increasing attention for its potential applications in assessing residual consciousness. However, the number of fNIRS studies assessing residual awareness in patients with pDoC is still limited. In this study, fNIRS was used to evaluate the brain function in 18 patients with pDoC, including 14 vegetative states (VS) and 4 minimally conscious states (MCS), and 15 healthy controls (HC). All participants accepted two types of external stimuli, i.e., active stimulation (motor imagery, MI) and passive stimulation (subject's own name, SON). The results showed that the mean concentrations of HbO/HbR in the prefrontal cortex of the HC during the passive stimulation were significantly lower than those of the active stimulation, and the fitting slope was high. However, the hemodynamic responses of the patients with pDoC were opposite to those of the HC. Additionally, the mean concentrations of HbO/HbR increased as the level of consciousness decreased during passive stimulation. Our findings suggest that the residual level of consciousness in pDoC patients can be assessed by measuring brain responses to different stimulations using fNIRS. The present study further demonstrates the feasibility and reliability of fNIRS in assessing residual consciousness in patients with pDoC, providing a basis for its expanded clinical application.
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